CFHR4
| Complement factor H-related 4 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | CFHR4 ; CFHL4; FHR-4; FHR4 | ||||||||||||
| External IDs | OMIM: 605337 HomoloGene: 136449 GeneCards: CFHR4 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10877 | n/a | |||||||||||
| Ensembl | ENSG00000134365 | n/a | |||||||||||
| UniProt | Q92496 | n/a | |||||||||||
| RefSeq (mRNA) | NM_001201550 | n/a | |||||||||||
| RefSeq (protein) | NP_001188479 | n/a | |||||||||||
| Location (UCSC) |
Chr 1: 196.85 – 196.92 Mb | n/a | |||||||||||
| PubMed search | n/a | ||||||||||||
Complement factor H-related protein 4 is a protein that in humans is encoded by the CFHR4 gene.[1][2][3]
References
- ↑ Skerka C, Hellwage J, Weber W, Tilkorn A, Buck F, Marti T, Kampen E, Beisiegel U, Zipfel PF (Apr 1997). "The human factor H-related protein 4 (FHR-4). A novel short consensus repeat-containing protein is associated with human triglyceride-rich lipoproteins". J Biol Chem 272 (9): 5627–34. doi:10.1074/jbc.272.9.5627. PMID 9038172.
- ↑ Diaz-Guillen MA, Rodriguez de Cordoba S, Heine-Suner D (Jul 1999). "A radiation hybrid map of complement factor H and factor H-related genes". Immunogenetics 49 (6): 549–52. doi:10.1007/s002510050534. PMID 10380701.
- ↑ "Entrez Gene: CFHR4 complement factor H-related 4".
Further reading
- Hageman GS, Hancox LS, Taiber AJ, et al. (2007). "Extended Haplotypes in the Complement Factor H (CFH) and CFH-related (CFHR) Family of Genes that Protect against Age-related Macular Degeneration: Identification, Ethnic Distribution and Evolutionary Implications". Ann. Med. 38 (8): 592–604. doi:10.1080/07853890601097030. PMC 1905836. PMID 17438673.
- Józsi M, Richter H, Löschmann I, et al. (2005). "FHR-4A: a new factor H-related protein is encoded by the human FHR-4 gene". Eur. J. Hum. Genet. 13 (3): 321–9. doi:10.1038/sj.ejhg.5201324. PMID 15562282.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hellwage J, Jokiranta TS, Koistinen V, et al. (2000). "Functional properties of complement factor H-related proteins FHR-3 and FHR-4: binding to the C3d region of C3b and differential regulation by heparin". FEBS Lett. 462 (3): 345–52. doi:10.1016/S0014-5793(99)01554-9. PMID 10622723.
- Hellwage J, Skerka C, Zipfel PF (1998). "Biochemical and functional characterization of the factor-H-related protein 4 (FHR-4)". Immunopharmacology 38 (1–2): 149–57. doi:10.1016/S0162-3109(97)00075-1. PMID 9476126.
External links
- GeneReviews/NCBI/NIH/UW entry on Atypical Hemolytic-Uremic Syndrome
- OMIM entries on Atypical Hemolytic-Uremic Syndrome
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