CFLAR

CASP8 and FADD-like apoptosis regulator
Rendering based on PDB 3H11​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3H11​, 3H13​
Identifiers
Symbols	CFLAR ; CASH; CASP8AP1; CLARP; Casper; FLAME; FLAME-1; FLAME1; FLIP; I-FLICE; MRIT; c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS
External IDs	OMIM: 603599 MGI: 1336166 HomoloGene: 7652 GeneCards: CFLAR Gene
Gene ontology Molecular function • protease binding • death receptor binding • protein binding • enzyme activator activity • protein complex binding • death effector domain binding • cysteine-type endopeptidase activity involved in apoptotic signaling pathway Cellular component • cytoplasm • cytosol • death-inducing signaling complex • CD95 death-inducing signaling complex • membrane raft • ripoptosome Biological process • apoptotic process • activation of cysteine-type endopeptidase activity involved in apoptotic process • skeletal muscle tissue development • regulation of necrotic cell death • programmed cell death • skeletal muscle atrophy • regulation of satellite cell proliferation • skeletal myofibril assembly • viral process • negative regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • skeletal muscle tissue regeneration • positive regulation of NF-kappaB transcription factor activity • regulation of necroptotic process • necroptotic process • extrinsic apoptotic signaling pathway • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • programmed necrotic cell death • negative regulation of myoblast fusion • regulation of extrinsic apoptotic signaling pathway via death domain receptors • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • negative regulation of extrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8837	12633
Ensembl	ENSG00000003402	ENSMUSG00000026031
UniProt	O15519	O35732
RefSeq (mRNA)	NM_001127183	NM_001289704
RefSeq (protein)	NP_001120655	NP_001276633
Location (UCSC)	Chr 2: 201.12 – 201.18 Mb	Chr 1: 58.71 – 58.76 Mb
PubMed search

CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene.^[1][2] Also called c-FLIP (FLICE-like inhibitory protein).

References

1. Shu HB, Halpin DR, Goeddel DV (Jul 1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity 6 (6): 751–63. doi:10.1016/S1074-7613(00)80450-1. PMID 9208847.
2. Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J (Jul 1997). "Inhibition of death receptor signals by cellular FLIP". Nature 388 (6638): 190–5. doi:10.1038/40657. PMID 9217161.

Further reading

• Abe K, Kurakin A, Mohseni-Maybodi M; et al. (2001). "The complexity of TNF-related apoptosis-inducing ligand.". Ann. N. Y. Acad. Sci. 926 (1): 52–63. doi:10.1111/j.1749-6632.2000.tb05598.x. PMID 11193041.
• Dutton A, Young LS, Murray PG (2006). "The role of cellular FLICE inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer.". Expert Opin. Ther. Targets 10 (1): 27–35. doi:10.1517/14728222.10.1.27. PMID 16441226.