CHD1L

Chromodomain helicase DNA binding protein 1-like
Identifiers
Symbols	CHD1L ; ALC1; CHDL
External IDs	OMIM: 613039 MGI: 1915308 HomoloGene: 11590 GeneCards: CHD1L Gene
EC number	3.6.4.12
Gene ontology Molecular function • nucleotide binding • nucleic acid binding • ATP-dependent DNA helicase activity • protein binding • ATP binding • ATPase activity Cellular component • nucleus • nucleoplasm • cytoplasm • plasma membrane Biological process • DNA repair • chromatin remodeling • cellular response to DNA damage stimulus • DNA duplex unwinding Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9557	68058
Ensembl	ENSG00000131778	ENSMUSG00000028089
UniProt	Q86WJ1	Q9CXF7
RefSeq (mRNA)	NM_001256336	NM_026539
RefSeq (protein)	NP_001243265	NP_080815
Location (UCSC)	Chr 1: 147.24 – 147.3 Mb	Chr 3: 97.56 – 97.61 Mb
PubMed search

Chromodomain-helicase-DNA-binding protein 1-like is an enzyme that in humans is encoded by the CHD1L gene.^[1][2] It has been implicated in chromatin remodeling and DNA relaxation process required for DNA replication, repair and transcription.

Related gene problems

• 1q21.1 deletion syndrome
• 1q21.1 duplication syndrome

With 1q21.1 deletion syndrome a disturbance occurs, which leads to increased DNA breaks. The role of CHD1L is similar to that of helicase with the Werner syndrome^[3]

References

1. Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
2. "Entrez Gene: CHD1L chromodomain helicase DNA binding protein 1-like".
3. Understanding the impact of 1q21.1 Copy Number Variant; C. Harvard et al; Orphanet Journal of Rare Diseases 2011, 6:54; doi:10.1186/1750-1172-6-54

Further reading

• Matoba R, Okubo K, Hori N; et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Zhang QH, Ye M, Wu XY; et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Harrington JJ, Sherf B, Rundlett S; et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Karras GI, Kustatscher G, Buhecha HR; et al. (2005). "The macro domain is an ADP-ribose binding module". EMBO J. 24 (11): 1911–20. doi:10.1038/sj.emboj.7600664. PMC 1142602. PMID 15902274.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.