CHMP2A

Charged multivesicular body protein 2A
Identifiers
Symbols	CHMP2A ; BC-2; BC2; CHMP2; VPS2; VPS2A
External IDs	OMIM: 610893 MGI: 1916203 HomoloGene: 6382 GeneCards: CHMP2A Gene
Gene ontology Molecular function • protein binding • protein domain specific binding • phosphatidylcholine binding Cellular component • cytosol • membrane • membrane coat • late endosome membrane • extracellular exosome Biological process • cell separation after cytokinesis • post-Golgi vesicle-mediated transport • nucleus organization • vacuolar transport • mitotic metaphase plate congression • membrane invagination • regulation of centrosome duplication • protein transport • viral process • endosomal transport • viral life cycle • viral budding via host ESCRT complex • establishment of protein localization • regulation of viral process • protein polymerization • protein homooligomerization • protein heterooligomerization • negative regulation of cell death • membrane organization • regulation of mitotic spindle assembly • positive regulation of viral release from host cell • positive regulation of exosomal secretion • negative regulation of centriole elongation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27243	68953
Ensembl	ENSG00000130724	ENSMUSG00000033916
UniProt	O43633	Q9DB34
RefSeq (mRNA)	NM_014453	NM_026885
RefSeq (protein)	NP_055268	NP_081161
Location (UCSC)	Chr 19: 58.55 – 58.56 Mb	Chr 7: 13.03 – 13.03 Mb
PubMed search

Charged multivesicular body protein 2a is a protein that in humans is encoded by the CHMP2A gene.^[1][2][3]

References

1. Fujita H, Umezuki Y, Imamura K, Ishikawa D, Uchimura S, Nara A, Yoshimori T, Hayashizaki Y, Kawai J, Ishidoh K, Tanaka Y, Himeno M (Jun 2004). "Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B". J Cell Sci 117 (Pt 14): 2997–3009. doi:10.1242/jcs.01170. PMID 15173323.
2. Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (Sep 2001). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J Cell Sci 114 (Pt 13): 2395–404. PMID 11559748.
3. "Entrez Gene: CHMP2A chromatin modifying protein 2A".

Further reading

• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L; et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Strack B, Calistri A, Craig S; et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding.". Cell 114 (6): 689–99. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569.
• von Schwedler UK, Stuchell M, Müller B; et al. (2003). "The protein network of HIV budding.". Cell 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570.
• Martin-Serrano J, Yarovoy A, Perez-Caballero D; et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nousiainen M, Silljé HH, Sauer G; et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Tsang HT, Connell JW, Brown SE; et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.". Genomics 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.