CHP (gene)

Calcineurin-like EF-hand protein 1
PDB rendering based on 2ct9.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2E30​
Identifiers
Symbols	CHP1 ; CHP; SLC9A1BP; Sid470p; p22; p24
External IDs	OMIM: 606988 MGI: 1927185 HomoloGene: 5235 GeneCards: CHP1 Gene
Gene ontology Molecular function • protein kinase inhibitor activity • transporter activity • calcium ion binding • protein binding • microtubule binding • potassium channel regulator activity • kinase binding • calcium-dependent protein binding Cellular component • Golgi membrane • nucleus • cytoplasm • endoplasmic reticulum • endoplasmic reticulum-Golgi intermediate compartment • cytosol • plasma membrane • focal adhesion • microtubule cytoskeleton • transport vesicle • extracellular exosome Biological process • microtubule bundle formation • negative regulation of protein phosphorylation • carbohydrate metabolic process • negative regulation of protein kinase activity • protein export from nucleus • potassium ion transport • small GTPase mediated signal transduction • negative regulation of phosphatase activity • calcium ion-dependent exocytosis • membrane docking • glycosaminoglycan metabolic process • hyaluronan metabolic process • hyaluronan catabolic process • cytoplasmic microtubule organization • negative regulation of protein ubiquitination • negative regulation of protein autophosphorylation • negative regulation of NF-kappaB transcription factor activity • positive regulation of sodium:proton antiporter activity • negative regulation of protein import into nucleus • small molecule metabolic process • protein stabilization • positive regulation of protein transport • protein oligomerization • regulation of intracellular pH • positive regulation of protein glycosylation • membrane organization • membrane fusion • negative regulation of calcineurin-NFAT signaling cascade • cellular response to acidic pH • positive regulation of protein targeting to membrane • regulation of neuron death • negative regulation of cyclin-dependent protein kinase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11261	56398
Ensembl	ENSG00000187446	ENSMUSG00000014077
UniProt	Q99653	P61022
RefSeq (mRNA)	NM_007236	NM_019769
RefSeq (protein)	NP_009167	NP_062743
Location (UCSC)	Chr 15: 41.23 – 41.28 Mb	Chr 2: 119.55 – 119.59 Mb
PubMed search

Calcium binding protein P22, also known as CHP, is a human gene.^[1]

Function

The protein encoded by this gene is a phosphoprotein that binds to the sodium-hydrogen exchangers (NHEs). This protein serves as an essential cofactor which supports the physiological activity of NHE family members. It has protein sequence similarity to calcineurin B and it is also known to be an endogenous inhibitor of calcineurin activity.^[1]

Interactions

CHP (gene) has been shown to interact with

• sodium-hydrogen antiporter 1,^[2][3][4]
• sodium-hydrogen antiporter 3,^[2] and
• sodium-hydrogen anti porter 9.^[5]

References

1. "Entrez Gene: CHP calcium binding protein P22".
2. Inoue H, Nakamura Y, Nagita M, Takai T, Masuda M, Nakamura N, Kanazawa H (Feb 2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium". Biological & Pharmaceutical Bulletin 26 (2): 148–55. doi:10.1248/bpb.26.148. PMID 12576672.
3. Lin X, Barber DL (Oct 1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proceedings of the National Academy of Sciences of the United States of America 93 (22): 12631–6. doi:10.1073/pnas.93.22.12631. PMC 38044. PMID 8901634.
4. Pang T, Su X, Wakabayashi S, Shigekawa M (May 2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". The Journal of Biological Chemistry 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981.
5. Zhang-James Y, DasBanerjee T, Sagvolden T, Middleton FA, Faraone SV (Dec 2011). "SLC9A9 mutations, gene expression, and protein-protein interactions in rat models of attention-deficit/hyperactivity disorder". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 156B (7): 835–43. doi:10.1002/ajmg.b.31229. PMID 21858920.

Further reading

• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (Sep 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
• Barroso MR, Bernd KK, DeWitt ND, Chang A, Mills K, Sztul ES (Apr 1996). "A novel Ca2+-binding protein, p22, is required for constitutive membrane traffic". The Journal of Biological Chemistry 271 (17): 10183–7. doi:10.1074/jbc.271.17.10183. PMID 8626580.
• Lin X, Barber DL (Oct 1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proceedings of the National Academy of Sciences of the United States of America 93 (22): 12631–6. doi:10.1073/pnas.93.22.12631. PMC 38044. PMID 8901634.
• Lin X, Sikkink RA, Rusnak F, Barber DL (Dec 1999). "Inhibition of calcineurin phosphatase activity by a calcineurin B homologous protein". The Journal of Biological Chemistry 274 (51): 36125–31. doi:10.1074/jbc.274.51.36125. PMID 10593895.
• Pang T, Su X, Wakabayashi S, Shigekawa M (May 2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". The Journal of Biological Chemistry 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981.
• Matsumoto M, Miyake Y, Nagita M, Inoue H, Shitakubo D, Takemoto K, Ohtsuka C, Murakami H, Nakamura N, Kanazawa H (Aug 2001). "A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na(+)/H(+) exchanger". Journal of Biochemistry 130 (2): 217–25. doi:10.1093/oxfordjournals.jbchem.a002975. PMID 11481038.
• Nakamura N, Miyake Y, Matsushita M, Tanaka S, Inoue H, Kanazawa H (Sep 2002). "KIF1Bbeta2, capable of interacting with CHP, is localized to synaptic vesicles". Journal of Biochemistry 132 (3): 483–91. doi:10.1093/oxfordjournals.jbchem.a003246. PMID 12204119.
• Pang T, Wakabayashi S, Shigekawa M (Nov 2002). "Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger". The Journal of Biological Chemistry 277 (46): 43771–7. doi:10.1074/jbc.M208313200. PMID 12226101.
• Inoue H, Nakamura Y, Nagita M, Takai T, Masuda M, Nakamura N, Kanazawa H (Feb 2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium". Biological & Pharmaceutical Bulletin 26 (2): 148–55. doi:10.1248/bpb.26.148. PMID 12576672.
• Pang T, Hisamitsu T, Mori H, Shigekawa M, Wakabayashi S (Mar 2004). "Role of calcineurin B homologous protein in pH regulation by the Na+/H+ exchanger 1: tightly bound Ca2+ ions as important structural elements". Biochemistry 43 (12): 3628–36. doi:10.1021/bi0360004. PMID 15035633.
• Andrade J, Pearce ST, Zhao H, Barroso M (Dec 2004). "Interactions among p22, glyceraldehyde-3-phosphate dehydrogenase and microtubules". The Biochemical Journal 384 (Pt 2): 327–36. doi:10.1042/BJ20040622. PMC 1134116. PMID 15312048.
• Ben Ammar Y, Takeda S, Sugawara M, Miyano M, Mori H, Wakabayashi S (Oct 2005). "Crystallization and preliminary crystallographic analysis of the human calcineurin homologous protein CHP2 bound to the cytoplasmic region of the Na+/H+ exchanger NHE1". Acta Crystallographica. Section F, Structural Biology and Crystallization Communications 61 (Pt 10): 956–8. doi:10.1107/S1744309105030836. PMC 1991313. PMID 16511206.
• Mishima M, Wakabayashi S, Kojima C (Jan 2007). "Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1". The Journal of Biological Chemistry 282 (4): 2741–51. doi:10.1074/jbc.M604092200. PMID 17050540.