CHST1

Carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
Identifiers
Symbols	CHST1 ; C6ST; GST-1; KS6ST; KSGal6ST; KSST
External IDs	OMIM: 603797 MGI: 1924219 HomoloGene: 2711 GeneCards: CHST1 Gene
EC number	2.8.2.21
Gene ontology Molecular function • sulfotransferase activity • keratan sulfotransferase activity Cellular component • Golgi membrane • integral component of membrane Biological process • carbohydrate metabolic process • polysaccharide metabolic process • galactose metabolic process • sulfur compound metabolic process • inflammatory response • keratan sulfate biosynthetic process • glycosaminoglycan metabolic process • keratan sulfate metabolic process • small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8534	76969
Ensembl	ENSG00000175264	ENSMUSG00000027221
UniProt	O43916	Q9EQC0
RefSeq (mRNA)	NM_003654	NM_023850
RefSeq (protein)	NP_003645	NP_076339
Location (UCSC)	Chr 11: 45.65 – 45.67 Mb	Chr 2: 92.6 – 92.62 Mb
PubMed search

Carbohydrate sulfotransferase 1 is an enzyme that in humans is encoded by the CHST1 gene.^[1][2][3]

References

1. Fukuta M, Inazawa J, Torii T, Tsuzuki K, Shimada E, Habuchi O (Jan 1998). "Molecular cloning and characterization of human keratan sulfate Gal-6-sulfotransferase". J Biol Chem 272 (51): 32321–8. doi:10.1074/jbc.272.51.32321. PMID 9405439.
2. Mazany KD, Peng T, Watson CE, Tabas I, Williams KJ (Aug 1998). "Human chondroitin 6-sulfotransferase: cloning, gene structure, and chromosomal localization". Biochim Biophys Acta 1407 (1): 92–7. doi:10.1016/s0925-4439(98)00028-3. PMID 9639683.
3. "Entrez Gene: CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1".

Further reading

• Williams KJ (1997). "Atherosclerosis: cell biology and lipoproteins.". Curr. Opin. Lipidol. 7 (6): U202–8. doi:10.1097/00041433-199612000-00016. PMID 9117134.
• Bernstein HB, Compans RW (1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein.". J. Virol. 66 (12): 6953–9. PMC 240329. PMID 1433500.
• Shilatifard A, Merkle RK, Helland DE; et al. (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine.". J. Virol. 67 (2): 943–52. PMC 237448. PMID 8419650.
• Li X, Tedder TF (1999). "CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization.". Genomics 55 (3): 345–7. doi:10.1006/geno.1998.5653. PMID 10049591.
• Bistrup A, Bhakta S, Lee JK; et al. (1999). "Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin.". J. Cell Biol. 145 (4): 899–910. doi:10.1083/jcb.145.4.899. PMC 2133194. PMID 10330415.
• Tu L, Murphy PG, Li X, Tedder TF (1999). "L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein ligand-1.". J. Immunol. 163 (9): 5070–8. PMID 10528213.
• Torii T, Fukuta M, Habuchi O (2000). "Sulfation of sialyl N-acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal-6-sulfotransferase.". Glycobiology 10 (2): 203–11. doi:10.1093/glycob/10.2.203. PMID 10642612.
• Li X, Tu L, Murphy PG; et al. (2001). "CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin.". J. Leukoc. Biol. 69 (4): 565–74. PMID 11310842.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yamada T, Ohtake S, Sato M, Habuchi O (2005). "Chondroitin 4-sulphotransferase-1 and chondroitin 6-sulphotransferase-1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues.". Biochem. J. 384 (Pt 3): 567–75. doi:10.1042/BJ20040965. PMC 1134142. PMID 15324304.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Liu J, Chau CH, Liu H; et al. (2006). "Upregulation of chondroitin 6-sulphotransferase-1 facilitates Schwann cell migration during axonal growth.". J. Cell. Sci. 119 (Pt 5): 933–42. doi:10.1242/jcs.02796. PMID 16495484.
• Kitayama K, Hayashida Y, Nishida K, Akama TO (2007). "Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans.". J. Biol. Chem. 282 (41): 30085–96. doi:10.1074/jbc.M703695200. PMID 17690104.