CHST10
| Carbohydrate sulfotransferase 10 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | CHST10 ; HNK-1ST; HNK1ST | ||||||||||||
| External IDs | OMIM: 606376 MGI: 2138283 HomoloGene: 21013 GeneCards: CHST10 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9486 | 98388 | |||||||||||
| Ensembl | ENSG00000115526 | ENSMUSG00000026080 | |||||||||||
| UniProt | O43529 | Q6PGK7 | |||||||||||
| RefSeq (mRNA) | NM_004854 | NM_145142 | |||||||||||
| RefSeq (protein) | NP_004845 | NP_660124 | |||||||||||
| Location (UCSC) |
Chr 2: 100.39 – 100.42 Mb |
Chr 1: 38.86 – 38.9 Mb | |||||||||||
| PubMed search | |||||||||||||
Carbohydrate sulfotransferase 10 is an enzyme that in humans is encoded by the CHST10 gene.[1][2]
Cell surface carbohydrates modulate a variety of cellular functions and are typically synthesized in a stepwise manner. HNK1ST plays a role in the biosynthesis of HNK1 (see MIM 151290), a neuronally expressed carbohydrate that contains a sulfoglucuronyl residue.[supplied by OMIM][2]
References
- ↑ Kang HG, Evers MR, Xia G, Baenziger JU, Schachner M (Sep 2002). "Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases". J Biol Chem 277 (38): 34766–72. doi:10.1074/jbc.M204907200. PMID 12080076.
- 1 2 "Entrez Gene: CHST10 carbohydrate sulfotransferase 10".
Further reading
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ong E, Yeh JC, Ding Y, et al. (1999). "Structure and function of HNK-1 sulfotransferase. Identification of donor and acceptor binding sites by site-directed mutagenesis". J. Biol. Chem. 274 (36): 25608–12. doi:10.1074/jbc.274.36.25608. PMID 10464296.
- Ong E, Yeh JC, Ding Y, et al. (1998). "Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids". J. Biol. Chem. 273 (9): 5190–5. doi:10.1074/jbc.273.9.5190. PMID 9478973.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Shilatifard A, Merkle RK, Helland DE, et al. (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine". J. Virol. 67 (2): 943–52. PMC 237448. PMID 8419650.
- Bernstein HB, Compans RW (1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein". J. Virol. 66 (12): 6953–9. PMC 240329. PMID 1433500.
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