CHST4

Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4

Identifiers

CHST4 ; GST3; GlcNAc6ST2; HECGLCNAC6ST; LSST

External IDs

MGI: 1349479 HomoloGene: 4216 ChEMBL: 2239 GeneCards: CHST4 Gene

Gene ontology
Molecular function	• N-acetylglucosamine 6-O-sulfotransferase activity • sulfotransferase activity
Cellular component	• trans-Golgi network • integral component of membrane • intrinsic component of Golgi membrane
Biological process	• carbohydrate metabolic process • N-acetylglucosamine metabolic process • protein sulfation • sulfur compound metabolic process • movement of cell or subcellular component • inflammatory response • immune response • cell adhesion • cell-cell signaling
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000140835

ENSMUSG00000035930

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 16:
71.53 – 71.54 Mb

Chr 8:
110.03 – 110.04 Mb

PubMed search

Carbohydrate sulfotransferase 4 is an enzyme that in humans is encoded by the CHST4 gene.^[1]^[2]

References

↑ Bistrup A, Bhakta S, Lee JK, Belov YY, Gunn MD, Zuo FR, Huang CC, Kannagi R, Rosen SD, Hemmerich S (Jul 1999). "Sulfotransferases of Two Specificities Function in the Reconstitution of High Endothelial Cell Ligands for L-selectin". J Cell Biol 145 (4): 899–910. doi:10.1083/jcb.145.4.899. PMC 2133194. PMID 10330415.
↑ "Entrez Gene: CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4".

Further reading

Bernstein HB, Compans RW (1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein". J. Virol. 66 (12): 6953–9. PMC 240329. PMID 1433500.
Shilatifard A, Merkle RK, Helland DE, et al. (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine". J. Virol. 67 (2): 943–52. PMC 237448. PMID 8419650.
Hemmerich S, Lee JK, Bhakta S, et al. (2001). "Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family". Glycobiology 11 (1): 75–87. doi:10.1093/glycob/11.1.75. PMID 11181564.
Li X, Tu L, Murphy PG, et al. (2001). "CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin". J. Leukoc. Biol. 69 (4): 565–74. PMID 11310842.
Yeh JC, Hiraoka N, Petryniak B, et al. (2001). "Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase". Cell 105 (7): 957–69. doi:10.1016/S0092-8674(01)00394-4. PMID 11439191.
Uchimura K, El-Fasakhany FM, Hori M, et al. (2002). "Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression". J. Biol. Chem. 277 (6): 3979–84. doi:10.1074/jbc.M106587200. PMID 11726653.
Seko A, Nagata K, Yonezawa S, Yamashita K (2003). "Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma". Glycobiology 12 (6): 379–88. doi:10.1093/glycob/12.6.379. PMID 12107080.
Akama TO, Misra AK, Hindsgaul O, Fukuda MN (2003). "Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate". J. Biol. Chem. 277 (45): 42505–13. doi:10.1074/jbc.M207412200. PMID 12218059.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
de Graffenried CL, Bertozzi CR (2003). "Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis". J. Biol. Chem. 278 (41): 40282–95. doi:10.1074/jbc.M304928200. PMID 12855678.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
de Graffenried CL, Bertozzi CR (2004). "The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity". J. Biol. Chem. 279 (38): 40035–43. doi:10.1074/jbc.M405709200. PMID 15220337.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Timson G, Banavali S, Gutierrez MI, et al. (2006). "High level expression of N-acetylgluosamine-6-O-sulfotransferase is characteristic of a subgroup of paediatric precursor-B acute lymphoblastic leukaemia". Cancer Lett. 242 (2): 239–44. doi:10.1016/j.canlet.2005.11.012. PMID 16386360.

External links

CHST4 human gene location in the UCSC Genome Browser.
CHST4 human gene details in the UCSC Genome Browser.

This article is issued from Wikipedia - version of the Sunday, July 26, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.