CHST5

Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
Identifiers
Symbols	CHST5 ; I-GlcNAc-6-ST; I-GlcNAc6ST; glcNAc6ST-3; gn6st-3; hIGn6ST
External IDs	OMIM: 604817 HomoloGene: 69379 GeneCards: CHST5 Gene
Gene ontology Molecular function • N-acetylglucosamine 6-O-sulfotransferase activity • sulfotransferase activity Cellular component • Golgi membrane • Golgi apparatus • integral component of membrane • intrinsic component of Golgi membrane Biological process • carbohydrate metabolic process • N-acetylglucosamine metabolic process • protein sulfation • sulfur compound metabolic process • keratan sulfate biosynthetic process • glycosaminoglycan metabolic process • keratan sulfate metabolic process • small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23563	n/a
Ensembl	ENSG00000135702	n/a
UniProt	Q9GZS9	n/a
RefSeq (mRNA)	NM_012126	n/a
RefSeq (protein)	NP_078809	n/a
Location (UCSC)	Chr 16: 75.53 – 75.54 Mb	n/a
PubMed search		n/a

Carbohydrate sulfotransferase 5 is an enzyme that in humans is encoded by the CHST5 gene.^[1][2][3]

References

1. Lee JK, Bhakta S, Rosen SD, Hemmerich S (Sep 1999). "Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue". Biochemical and Biophysical Research Communications 263 (2): 543–9. doi:10.1006/bbrc.1999.1324. PMID 10491328.
2. Akama TO, Nishida K, Nakayama J, Watanabe H, Ozaki K, Nakamura T, Dota A, Kawasaki S, Inoue Y, Maeda N, Yamamoto S, Fujiwara T, Thonar EJ, Shimomura Y, Kinoshita S, Tanigami A, Fukuda MN (Oct 2000). "Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene". Nature Genetics 26 (2): 237–41. doi:10.1038/79987. PMID 11017086.
3. "Entrez Gene: CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5".

Further reading

• Bernstein HB, Compans RW (Dec 1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein". Journal of Virology 66 (12): 6953–9. PMC 240329. PMID 1433500.
• Shilatifard A, Merkle RK, Helland DE, Welles JL, Haseltine WA, Cummings RD (Feb 1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine". Journal of Virology 67 (2): 943–52. PMC 237448. PMID 8419650.
• Bartes A, Bhakta S, Hemmerich S (Apr 2001). "Sulfation of endothelial mucin by corneal keratan N-acetylglucosamine 6-O-sulfotransferase (GST-4beta)". Biochemical and Biophysical Research Communications 282 (4): 928–33. doi:10.1006/bbrc.2001.4668. PMID 11352640.
• Seko A, Nagata K, Yonezawa S, Yamashita K (Jun 2002). "Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma". Glycobiology 12 (6): 379–88. doi:10.1093/glycob/12.6.379. PMID 12107080.
• Akama TO, Misra AK, Hindsgaul O, Fukuda MN (Nov 2002). "Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate". The Journal of Biological Chemistry 277 (45): 42505–13. doi:10.1074/jbc.M207412200. PMID 12218059.
• Lee JK, Bistrup A, van Zante A, Rosen SD (Apr 2003). "Activities and expression pattern of the carbohydrate sulfotransferase GlcNAc6ST-3 (I-GlcNAc6ST): functional implications". Glycobiology 13 (4): 245–54. doi:10.1093/glycob/cwg018. PMID 12626414.
• de Graffenried CL, Bertozzi CR (Oct 2003). "Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis". The Journal of Biological Chemistry 278 (41): 40282–95. doi:10.1074/jbc.M304928200. PMID 12855678.
• Kitayama K, Hayashida Y, Nishida K, Akama TO (Oct 2007). "Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans". The Journal of Biological Chemistry 282 (41): 30085–96. doi:10.1074/jbc.M703695200. PMID 17690104.