CHST7

Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
Identifiers
Symbols	CHST7 ; C6ST-2; GST-5
External IDs	OMIM: 300375 MGI: 1891767 HomoloGene: 10531 GeneCards: CHST7 Gene
EC number	2.8.2.17
Gene ontology Molecular function • N-acetylglucosamine 6-O-sulfotransferase activity • chondroitin 6-sulfotransferase activity Cellular component • Golgi membrane • integral component of membrane Biological process • carbohydrate metabolic process • polysaccharide metabolic process • N-acetylglucosamine metabolic process • sulfur compound metabolic process • glycosaminoglycan metabolic process • chondroitin sulfate metabolic process • chondroitin sulfate biosynthetic process • small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	56548	60322
Ensembl	ENSG00000147119	ENSMUSG00000037347
UniProt	Q9NS84	Q9EP78
RefSeq (mRNA)	NM_019886	NM_021715
RefSeq (protein)	NP_063939	NP_068361
Location (UCSC)	Chr X: 46.57 – 46.6 Mb	Chr X: 20.06 – 20.1 Mb
PubMed search

Carbohydrate sulfotransferase 7 is an enzyme that in humans is encoded by the CHST7 gene.^[1][2]

Function

This gene belongs to the sulfotransferase gene family. Sulfotransferases generate sulfated glycosaminoglycan (GAG) moities during chondroitin sulfate biosynthesis. They create considerable structural diversity among chondroitin sulfates by transferring sulfate with remarkable specificity for the underlying oligosaccharide substrate. This gene product mainly transfers sulfate to N-acetylgalactosamine. The regulated expression of each member of this gene family may be an important determinant of sulfated GAGs expression and the associated function of chondroitin sulfates as regulators of many biologic processes. This gene is part of a gene cluster on chromosome Xp11.23.^[2]

References

1. Kitagawa H, Fujita M, Ito N, Sugahara K (Aug 2000). "Molecular cloning and expression of a novel chondroitin 6-O-sulfotransferase". J Biol Chem 275 (28): 21075–80. doi:10.1074/jbc.M002101200. PMID 10781596.
2. "Entrez Gene: CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7".

Further reading

• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Thiselton DL, McDowall J, Brandau O, et al. (2002). "An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders". Genomics 79 (4): 560–72. doi:10.1006/geno.2002.6733. PMID 11944989.
• Bhakta S, Bartes A, Bowman KG, et al. (2001). "Sulfation of N-acetylglucosamine by chondroitin 6-sulfotransferase 2 (GST-5)". J. Biol. Chem. 275 (51): 40226–34. doi:10.1074/jbc.M006414200. PMID 10956661.
• Uchimura K, Fasakhany F, Kadomatsu K, et al. (2000). "Diversity of N-acetylglucosamine-6-O-sulfotransferases: molecular cloning of a novel enzyme with different distribution and specificities". Biochem. Biophys. Res. Commun. 274 (2): 291–6. doi:10.1006/bbrc.2000.3141. PMID 10913333.
• Shilatifard A, Merkle RK, Helland DE, et al. (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine". J. Virol. 67 (2): 943–52. PMC 237448. PMID 8419650.
• Bernstein HB, Compans RW (1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein". J. Virol. 66 (12): 6953–9. PMC 240329. PMID 1433500.