CIC (gene)

Capicua transcriptional repressor
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2M41​, 4J2J​, 4J2L​
Identifiers
Symbols	CIC ; KIAA0306
External IDs	OMIM: 612082 MGI: 1918972 HomoloGene: 87637 GeneCards: CIC Gene
Gene ontology Molecular function • DNA binding • chromatin binding • protein binding Cellular component • nucleus Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • lung alveolus development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23152	71722
Ensembl	ENSG00000079432	ENSMUSG00000005442
UniProt	Q96RK0	Q924A2
RefSeq (mRNA)	NM_001304815	NM_001110131
RefSeq (protein)	NP_001291744	NP_001289740
Location (UCSC)	Chr 19: 42.27 – 42.3 Mb	Chr 7: 25.27 – 25.29 Mb
PubMed search

Protein capicua homolog is a protein that in humans is encoded by the CIC gene.^[1][2][3]

References

1. Lee CJ, Chan WI, Cheung M, Cheng YC, Appleby VJ, Orme AT, Scotting PJ (Oct 2002). "CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons". Brain Res Mol Brain Res 106 (1–2): 151–6. doi:10.1016/S0169-328X(02)00439-4. PMID 12393275.
2. Lee CJ, Chan WI, Scotting PJ (Jun 2005). "CIC, a gene involved in cerebellar development and ErbB signaling, is significantly expressed in medulloblastomas". J Neurooncol 73 (2): 101–8. doi:10.1007/s11060-004-4598-2. PMID 15981098.
3. "Entrez Gene: CIC capicua transcriptional repressor [ Homo sapiens (human) ]".

Further reading

• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Ballif BA, Villén J, Beausoleil SA; et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Nagase T, Ishikawa K, Nakajima D; et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.