CISH

This article is about the CISH gene. For other uses, see chromogenic in situ hybridization.
Cytokine inducible SH2-containing protein
Identifiers
Symbols CISH ; BACTS2; CIS; CIS-1; G18; SOCS
External IDs OMIM: 602441 MGI: 103159 HomoloGene: 7667 GeneCards: CISH Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 1154 12700
Ensembl ENSG00000114737 ENSMUSG00000032578
UniProt Q9NSE2 Q62225
RefSeq (mRNA) NM_013324 NM_009895
RefSeq (protein) NP_037456 NP_034025
Location (UCSC) Chr 3:
50.61 – 50.61 Mb		 Chr 9:
107.3 – 107.3 Mb
PubMed search

Cytokine-inducible SH2-containing protein is a protein that in humans is encoded by the CISH gene.[1][2][3] CISH orthologs [4] have been identified in most mammals with sequenced genomes. CISH controls T cell receptor (TCR) signaling, and variations of CISH with certain SNPs are associated with susceptibility to bacteremia, tuberculosis and malaria.[5]

Function

The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL-2, IL-3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor.[3]

CISH is induced by T cell receptor (TCR) ligation and negatively regulates it by targeting the critical signaling intermediate PLC-gamma-1 for degradation.[6] The deletion of Cish in effector T cells has been shown to augment TCR signaling and subsequent effector cytokine release, proliferation and survival. The adoptive transfer of tumor-specific effector T cells knocked out or knocked down for CISH resulted in a significant increase in functional avidity and long-term tumor immunity. There are no changes in activity or phosphorylation of Cish's purported target, STAT5 in either the presence or absence of Cish.

Model organisms

Model organisms have been used in the study of CISH function. A conditional knockout mouse line, called Cishtm1a(KOMP)Wtsi[11][12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[13][14][15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][16] Twenty four tests were carried out on mutant mice, however no significant abnormalities were observed.[9]

Interactions

CISH has been shown to interact with IL2RB[17] and Growth hormone receptor.[18] and PLCG1.[6]

References

  1. ↑ Uchida K, Yoshimura A, Inazawa J, Yanagisawa K, Osada H, Masuda A, Saito T, Takahashi T, Miyajima A, Takahashi T (Mar 1998). "Molecular cloning of CISH, chromosome assignment to 3p21.3, and analysis of expression in fetal and adult tissues". Cytogenetics and Cell Genetics 78 (3-4): 209–12. doi:10.1159/000134658. PMID 9465889.
  2. ↑ Yoshimura A, Ohkubo T, Kiguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Hara T, Miyajima A (Jun 1995). "A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors". The EMBO Journal 14 (12): 2816–26. PMC 398400. PMID 7796808.
  3. 1 2 "Entrez Gene: CISH cytokine inducible SH2-containing protein".
  4. ↑ "OrthoMaM phylogenetic marker: CISH coding sequence".
  5. ↑ Khor CC, Vannberg FO, Chapman SJ, Guo H, Wong SH, Walley AJ, Vukcevic D, Rautanen A, Mills TC, Chang KC, Kam KM, Crampin AC, Ngwira B, Leung CC, Tam CM, Chan CY, Sung JJ, Yew WW, Toh KY, Tay SK, Kwiatkowski D, Lienhardt C, Hien TT, Day NP, Peshu N, Marsh K, Maitland K, Scott JA, Williams TN, Berkley JA, Floyd S, Tang NL, Fine PE, Goh DL, Hill AV (Jun 2010). "CISH and susceptibility to infectious diseases". The New England Journal of Medicine 362 (22): 2092–101. doi:10.1056/NEJMoa0905606. PMID 20484391. [Free Text]
  6. 1 2 Palmer DC, Guittard GC, Franco Z, Crompton JG, Eil RL, Patel SJ, Ji Y, Van Panhuys N, Klebanoff CA, Sukumar M, Clever D, Chichura A, Roychoudhuri R, Varma R, Wang E, Gattinoni L, Marincola FM, Balagopalan L, Samelson LE, Restifo NP (Nov 2015). "Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance". The Journal of Experimental Medicine. doi:10.1084/jem.20150304. PMID 26527801.
  7. ↑ "Salmonella infection data for Cish". Wellcome Trust Sanger Institute.
  8. ↑ "Citrobacter infection data for Cish". Wellcome Trust Sanger Institute.
  9. 1 2 3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
  10. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  11. ↑ "International Knockout Mouse Consortium".
  12. ↑ "Mouse Genome Informatics".
  13. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  14. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  15. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  16. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
  17. ↑ Aman MJ, Migone TS, Sasaki A, Ascherman DP, Zhu MH, Soldaini E, Imada K, Miyajima A, Yoshimura A, Leonard WJ (Oct 1999). "CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling". The Journal of Biological Chemistry 274 (42): 30266–72. doi:10.1074/jbc.274.42.30266. PMID 10514520.
  18. ↑ Ram PA, Waxman DJ (Dec 1999). "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms". The Journal of Biological Chemistry 274 (50): 35553–61. doi:10.1074/jbc.274.50.35553. PMID 10585430.

Further reading

  • Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (May 2002). "The SOCS box: a tale of destruction and degradation". Trends in Biochemical Sciences 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535. 
  • Verdier F, Chrétien S, Muller O, Varlet P, Yoshimura A, Gisselbrecht S, Lacombe C, Mayeux P (Oct 1998). "Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein". The Journal of Biological Chemistry 273 (43): 28185–90. doi:10.1074/jbc.273.43.28185. PMID 9774439. 
  • Okabe S, Tauchi T, Morita H, Ohashi H, Yoshimura A, Ohyashiki K (Oct 1999). "Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway". Experimental Hematology 27 (10): 1542–7. doi:10.1016/S0301-472X(99)00094-6. PMID 10517496. 
  • Jiang C, Yu L, Zhao Y, Zhang M, Liu Q, Mao N, Geng Z, Zhao S (2000). "Cloning and characterization of CIS 1b (cytokine inducible SH2-containing protein 1b), an alternative splicing form of CIS 1 gene". DNA Sequence 11 (1-2): 149–54. doi:10.3109/10425170009033983. PMID 10902923. 
  • Dogusan Z, Hooghe-Peters EL, Berus D, Velkeniers B, Hooghe R (Sep 2000). "Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines". Journal of Neuroimmunology 109 (1): 34–9. doi:10.1016/S0165-5728(00)00300-3. PMID 10969179. 
  • Yousefi S, Cooper PR, Mueck B, Potter SL, Jarai G (Oct 2000). "cDNA representational difference analysis of human neutrophils stimulated by GM-CSF". Biochemical and Biophysical Research Communications 277 (2): 401–9. doi:10.1006/bbrc.2000.3678. PMID 11032736. 
  • Dif F, Saunier E, Demeneix B, Kelly PA, Edery M (Dec 2001). "Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor". Endocrinology 142 (12): 5286–93. doi:10.1210/endo.142.12.8549. PMID 11713228. 
  • Federici M, Giustizieri ML, Scarponi C, Girolomoni G, Albanesi C (Jul 2002). "Impaired IFN-gamma-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling 1". Journal of Immunology 169 (1): 434–42. doi:10.4049/jimmunol.169.1.434. PMID 12077274. 
  • Du L, Frick GP, Tai LR, Yoshimura A, Goodman HM (Mar 2003). "Interaction of the growth hormone receptor with cytokine-induced Src homology domain 2 protein in rat adipocytes". Endocrinology 144 (3): 868–76. doi:10.1210/en.2002-220830. PMID 12586763. 
  • Chen S, Anderson PO, Li L, Sjögren HO, Wang P, Li SL (Mar 2003). "Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells". International Immunology 15 (3): 403–9. doi:10.1093/intimm/dxg039. PMID 12618484. 
  • Yamasaki K, Hanakawa Y, Tokumaru S, Shirakata Y, Sayama K, Hanada T, Yoshimura A, Hashimoto K (Apr 2003). "Suppressor of cytokine signaling 1/JAB and suppressor of cytokine signaling 3/cytokine-inducible SH2 containing protein 3 negatively regulate the signal transducers and activators of transcription signaling pathway in normal human epidermal keratinocytes". The Journal of Investigative Dermatology 120 (4): 571–80. doi:10.1046/j.1523-1747.2003.12100.x. PMID 12648219. 
  • Cheng J, Zhang D, Zhou C, Marasco WA (Jan 2004). "Down-regulation of SHP1 and up-regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transformed human peripheral blood CD4+ T-cells". Leukemia Research 28 (1): 71–82. doi:10.1016/S0145-2126(03)00158-9. PMID 14630083. 
  • Bayle J, Letard S, Frank R, Dubreuil P, De Sepulveda P (Mar 2004). "Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling". The Journal of Biological Chemistry 279 (13): 12249–59. doi:10.1074/jbc.M313381200. PMID 14707129. 
  • Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. 
  • Hunter MG, Jacob A, O'donnell LC, Agler A, Druhan LJ, Coggeshall KM, Avalos BR (Oct 2004). "Loss of SHIP and CIS recruitment to the granulocyte colony-stimulating factor receptor contribute to hyperproliferative responses in severe congenital neutropenia/acute myelogenous leukemia". Journal of Immunology 173 (8): 5036–45. doi:10.4049/jimmunol.173.8.5036. PMID 15470047. 
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