CITED1

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
Identifiers
Symbols	CITED1 ; MSG1
External IDs	OMIM: 300149 MGI: 108023 HomoloGene: 3057 GeneCards: CITED1 Gene
Gene ontology Molecular function • chromatin binding • transcription factor activity, sequence-specific DNA binding • transcription coactivator activity • protein binding • protein C-terminus binding • protein homodimerization activity • transcription regulatory region DNA binding • LBD domain binding • co-SMAD binding Cellular component • nucleus • cytoplasm • cytosol Biological process • embryonic axis specification • vasculogenesis • metanephros development • branching involved in ureteric bud morphogenesis • placenta development • negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • nucleocytoplasmic transport • apoptotic process • transforming growth factor beta receptor signaling pathway • brain development • cell proliferation • positive regulation of gene expression • negative regulation of Wnt signaling pathway • melanocyte differentiation • positive regulation of transforming growth factor beta receptor signaling pathway • response to lipopolysaccharide • response to insulin • response to cytokine • response to interferon-gamma • melanin biosynthetic process • pigmentation • negative regulation of neuron apoptotic process • response to estrogen • negative regulation of osteoblast differentiation • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • response to cAMP • mesenchymal to epithelial transition • SMAD protein signal transduction • labyrinthine layer development • spongiotrophoblast layer development • response to interleukin-1 • response to interleukin-2 • response to interleukin-4 • response to interleukin-6 • response to interleukin-9 • response to interleukin-11 • response to parathyroid hormone • response to transforming growth factor beta Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4435	12705
Ensembl	ENSG00000125931	ENSMUSG00000051159
UniProt	Q99966	P97769
RefSeq (mRNA)	NM_001144885	NM_001276466
RefSeq (protein)	NP_001138357	NP_001263395
Location (UCSC)	Chr X: 72.3 – 72.31 Mb	Chr X: 102.25 – 102.25 Mb
PubMed search

Cbp/p300-interacting transactivator 1 is a protein that in humans is encoded by the CITED1 gene.^[1][2][3]

Interactions

CITED1 has been shown to interact with HSPA8^[4] and EP300.^[4]

References

1. Shioda T, Fenner MH, Isselbacher KJ (December 1996). "msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation". Proc Natl Acad Sci U S A 93 (22): 12298–303. doi:10.1073/pnas.93.22.12298. PMC 37985. PMID 8901575.
2. Fenner MH, Parrish JE, Boyd Y, Reed V, MacDonald M, Nelson DL, Isselbacher KJ, Shioda T (October 1998). "MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis". Genomics 51 (3): 401–7. doi:10.1006/geno.1998.5383. PMID 9721210.
3. "Entrez Gene: CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1".
4. Yahata, T; de Caestecker M P; Lechleider R J; Andriole S; Roberts A B; Isselbacher K J; Shioda T (March 2000). "The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors". J. Biol. Chem. (UNITED STATES) 275 (12): 8825–34. doi:10.1074/jbc.275.12.8825. ISSN 0021-9258. PMID 10722728.

Further reading

• Shioda T, Fenner MH, Isselbacher KJ (1998). "MSG1 and its related protein MRG1 share a transcription activating domain.". Gene 204 (1–2): 235–41. doi:10.1016/S0378-1119(97)00551-9. PMID 9434189.
• Li H, Ahmed NU, Fenner MH; et al. (1998). "Regulation of expression of MSG1 melanocyte-specific nuclear protein in human melanocytes and melanoma cells". Exp. Cell Res. 242 (2): 478–86. doi:10.1006/excr.1998.4123. PMID 9683535.
• Shioda T, Lechleider RJ, Dunwoodie SL; et al. (1998). "Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9785–90. doi:10.1073/pnas.95.17.9785. PMC 21414. PMID 9707553.
• Vachtenheim J, Novotná H (2000). "Expression of genes for microphthalmia isoforms, Pax3 and MSG1, in human melanomas". Cell. Mol. Biol. (Noisy-le-grand) 45 (7): 1075–82. PMID 10644012.
• Yahata T, de Caestecker MP, Lechleider RJ; et al. (2000). "The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors". J. Biol. Chem. 275 (12): 8825–34. doi:10.1074/jbc.275.12.8825. PMID 10722728.
• Ahmed NU, Shioda T, Coser KR; et al. (2001). "Aberrant expression of MSG1 transcriptional activator in human malignant melanoma in vivo". Pigment Cell Res. 14 (2): 140–3. PMID 11310794.
• Iwasaki T, Chin WW, Ko L (2001). "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)". J. Biol. Chem. 276 (36): 33375–83. doi:10.1074/jbc.M101517200. PMID 11443112.
• Yahata T, Shao W, Endoh H; et al. (2001). "Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein". Genes Dev. 15 (19): 2598–612. doi:10.1101/gad.906301. PMC 312794. PMID 11581164.
• Bragança J, Swingler T, Marques FI; et al. (2002). "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2". J. Biol. Chem. 277 (10): 8559–65. doi:10.1074/jbc.M110850200. PMID 11744733.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Shi G, Boyle SC, Sparrow DB; et al. (2006). "The transcriptional activity of CITED1 is regulated by phosphorylation in a cell cycle-dependent manner". J. Biol. Chem. 281 (37): 27426–35. doi:10.1074/jbc.M602631200. PMID 16864582.
• Lovvorn HN, Westrup J, Opperman S; et al. (2007). "CITED1 expression in Wilms' tumor and embryonic kidney". Neoplasia 9 (7): 589–600. doi:10.1593/neo.07358. PMC 1941694. PMID 17710162.