CIZ1

CDKN1A interacting zinc finger protein 1
Identifiers
Symbols	CIZ1 ; LSFR1; NP94; ZNF356
External IDs	OMIM: 611420 MGI: 1920234 HomoloGene: 8112 GeneCards: CIZ1 Gene
Gene ontology Molecular function • nucleic acid binding • protein binding • zinc ion binding Cellular component • nucleus Biological process • positive regulation of DNA-dependent DNA replication initiation • maintenance of protein location in nucleus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	25792	68379
Ensembl	ENSG00000148337	ENSMUSG00000039205
UniProt	Q9ULV3	Q3TXU6
RefSeq (mRNA)	NM_001131015	NM_001252534
RefSeq (protein)	NP_001124487	NP_001239463
Location (UCSC)	Chr 9: 128.17 – 128.2 Mb	Chr 2: 32.35 – 32.38 Mb
PubMed search

Cip1-interacting zinc finger protein is a protein that in humans is encoded by the CIZ1 gene.^[1][2]

Function

The protein encoded by this gene is a zinc finger DNA binding transcription factor that interacts with CIP1 (p21 / CDKN1A), part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1.^[2]

Clinical significance

An altered circulating form of the Ciz1 protein is synthesized by lung cancer cells, even when they are at a very early stage. Hence detection of this protein variant in blood could be used as a biomarker for early detection of lung cancer.^[3]

Interactions

CIZ1 has been shown to interact with P21.^[1]

References

1. Mitsui K, Matsumoto A, Ohtsuka S, Ohtsubo M, Yoshimura A (Dec 1999). "Cloning and characterization of a novel p21(Cip1/Waf1)-interacting zinc finger protein, ciz1". Biochem Biophys Res Commun 264 (2): 457–64. doi:10.1006/bbrc.1999.1516. PMID 10529385.
2. "Entrez Gene: CIZ1 CDKN1A interacting zinc finger protein 1".
3. Higgins G, Roper KM, Watson IJ, Blackhall FH, Rom WN, Pass HI, Ainscough JF, Coverley D (October 2012). "Variant Ciz1 is a circulating biomarker for early-stage lung cancer". Proc. Natl. Acad. Sci. U.S.A. 109 (45): E3128–35. doi:10.1073/pnas.1210107109. PMID 23074256.

Further reading

• Lukasik A, Uniewicz KA, Kulis M, Kozlowski P (2008). "Ciz1, a p21 cip1/Waf1-interacting zinc finger protein and DNA replication factor, is a novel molecular partner for human enhancer of rudimentary homolog.". FEBS J. 275 (2): 332–40. doi:10.1111/j.1742-4658.2007.06203.x. PMID 18081865.
• Rahman FA, Ainscough JF, Copeland N, Coverley D (2007). "Cancer-associated missplicing of exon 4 influences the subnuclear distribution of the DNA replication factor CIZ1.". Hum. Mutat. 28 (10): 993–1004. doi:10.1002/humu.20550. PMID 17508423.
• den Hollander P, Rayala SK, Coverley D, Kumar R (2006). "Ciz1, a Novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen action.". Cancer Res. 66 (22): 11021–9. doi:10.1158/0008-5472.CAN-06-2336. PMID 17108141.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Coverley D, Marr J, Ainscough J (2005). "Ciz1 promotes mammalian DNA replication.". J. Cell. Sci. 118 (Pt 1): 101–12. doi:10.1242/jcs.01599. PMID 15585571.
• Warder DE, Keherly MJ (2004). "Ciz1, Cip1 interacting zinc finger protein 1 binds the consensus DNA sequence ARYSR(0-2)YYAC.". J. Biomed. Sci. 10 (4): 406–17. doi:10.1159/000071160. PMID 12824700.
• Gilley J, Fried M (1999). "Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes.". Hum. Mol. Genet. 8 (7): 1313–20. doi:10.1093/hmg/8.7.1313. PMID 10369878.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.