CLASP2

Cytoplasmic linker associated protein 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3WOY​
Identifiers
Symbol	CLASP2
External IDs	OMIM: 605853 MGI: 1923749 HomoloGene: 24944 GeneCards: CLASP2 Gene
Gene ontology Molecular function • dystroglycan binding • protein binding • microtubule binding • microtubule plus-end binding Cellular component • kinetochore • condensed chromosome kinetochore • cytoplasm • Golgi apparatus • trans-Golgi network • microtubule organizing center • kinetochore microtubule • cytosol • microtubule • cytoplasmic microtubule • plasma membrane • focal adhesion • cell cortex • membrane • cell leading edge • ruffle membrane • basal cortex • mitotic spindle Biological process • microtubule cytoskeleton organization • mitotic cell cycle • vesicle targeting • microtubule nucleation • negative regulation of microtubule depolymerization • Golgi organization • mitotic spindle organization • establishment or maintenance of cell polarity • small GTPase mediated signal transduction • axon guidance • exit from mitosis • regulation of gastrulation • positive regulation of epithelial cell migration • regulation of epithelial to mesenchymal transition • microtubule organizing center organization • regulation of microtubule polymerization or depolymerization • regulation of microtubule-based process • microtubule anchoring • positive regulation of exocytosis • cell division • negative regulation of stress fiber assembly • negative regulation of focal adhesion assembly • establishment of protein localization to plasma membrane • positive regulation of extracellular matrix disassembly • negative regulation of wound healing, spreading of epidermal cells • positive regulation of basement membrane assembly involved in embryonic body morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23122	76499
Ensembl	ENSG00000163539	ENSMUSG00000033392
UniProt	O75122	Q8BRT1
RefSeq (mRNA)	NM_001207044	NM_001081960
RefSeq (protein)	NP_001193973	NP_001075429
Location (UCSC)	Chr 3: 33.5 – 33.72 Mb	Chr 9: 113.81 – 113.92 Mb
PubMed search

Cytoplasmic linker associated protein 2, also known as CLASP2, is a protein which in humans is encoded by the CLASP2 gene.^[1]

References

1. "Entrez Gene: CLASP2 cytoplasmic linker associated protein 2".

Further reading

• Galjart N (2005). "CLIPs and CLASPs and cellular dynamics.". Nat. Rev. Mol. Cell Biol. 6 (6): 487–98. doi:10.1038/nrm1664. PMID 15928712.
• Ishikawa K, Nagase T, Suyama M; et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
• Lemos CL, Sampaio P, Maiato H; et al. (2000). "Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization.". EMBO J. 19 (14): 3668–82. doi:10.1093/emboj/19.14.3668. PMC 313969. PMID 10899121.
• Akhmanova A, Hoogenraad CC, Drabek K; et al. (2001). "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts.". Cell 104 (6): 923–35. doi:10.1016/S0092-8674(01)00288-4. PMID 11290329.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Maiato H, Fairley EA, Rieder CL; et al. (2003). "Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics.". Cell 113 (7): 891–904. doi:10.1016/S0092-8674(03)00465-3. PMID 12837247.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lee H, Engel U, Rusch J; et al. (2004). "The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance.". Neuron 42 (6): 913–26. doi:10.1016/j.neuron.2004.05.020. PMID 15207236.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mimori-Kiyosue Y, Grigoriev I, Lansbergen G; et al. (2005). "CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex.". J. Cell Biol. 168 (1): 141–53. doi:10.1083/jcb.200405094. PMC 2171674. PMID 15631994.
• Wittmann T, Waterman-Storer CM (2005). "Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells.". J. Cell Biol. 169 (6): 929–39. doi:10.1083/jcb.200412114. PMC 2171640. PMID 15955847.
• Lansbergen G, Grigoriev I, Mimori-Kiyosue Y; et al. (2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta.". Dev. Cell 11 (1): 21–32. doi:10.1016/j.devcel.2006.05.012. PMID 16824950.
• Mimori-Kiyosue Y, Grigoriev I, Sasaki H; et al. (2006). "Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment.". Genes Cells 11 (8): 845–57. doi:10.1111/j.1365-2443.2006.00990.x. PMID 16866869.
• Pereira AL, Pereira AJ, Maia AR; et al. (2007). "Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function.". Mol. Biol. Cell 17 (10): 4526–42. doi:10.1091/mbc.E06-07-0579. PMC 1635371. PMID 16914514.
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.