CLCF1

Cardiotrophin-like cytokine factor 1
Identifiers
Symbols CLCF1 ; BSF-3; BSF3; CISS2; CLC; NNT-1; NNT1; NR6
External IDs OMIM: 607672 MGI: 1930088 HomoloGene: 8299 GeneCards: CLCF1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 23529 56708
Ensembl ENSG00000175505 ENSMUSG00000040663
UniProt Q9UBD9 Q9QZM3
RefSeq (mRNA) NM_001166212 NM_001310038
RefSeq (protein) NP_001159684 NP_001296967
Location (UCSC) Chr 11:
67.36 – 67.37 Mb
Chr 19:
4.21 – 4.22 Mb
PubMed search

Cardiotrophin-like cytokine factor 1 (CLCF1), also known as Novel Neurotrophin-1 (NNT-1) or B cell-stimulating factor-3 (BSF-3), is a protein that in humans is encoded by the CLCF1 gene.[1]

Function

CLCF1 induces tyrosine phosphorylation of the IL-6 receptor common subunit glycoprotein 130 (gp130), leukemia inhibitory factor receptor beta, and the transcription factor STAT3. It has been implicated in the induction of IL-1 (via induction of corticosterone and IL-6) and serum amyloid A, and in B cell hyperplasia. This cytokine is capable of B cell activation via gp130 receptor stimulation.[2]

Structure

CLCF1 is a cytokine belonging to the interleukin-6 (IL6) family. It is a secreted protein, found predominantly in lymph nodes and spleen, and contains 225 amino acids with a molecular mass of 22 kDa in its mature form. IL6 family members share similarity in gene structure and have a 4-helix bundle in their protein structure. CLCF1 is closely related to other proteins called cardiotrophin-1 and ciliary neurotrophic factor.

References

  1. "Entrez Gene: CLCF1 cardiotrophin-like cytokine factor 1".
  2. Senaldi G, Varnum BC, Sarmiento U, Starnes C, Lile J, Scully S, Guo J, Elliott G, McNinch J, Shaklee CL, Freeman D, Manu F, Simonet WS, Boone T, Chang MS (September 1999). "Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11458–63. doi:10.1073/pnas.96.20.11458. PMC 18055. PMID 10500198.

Further reading

External links


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