CLDN22

Claudin 22
Identifiers
Symbols	CLDN22 ; CLDN21
External IDs	HomoloGene: 129823 GeneCards: CLDN22 Gene
Gene ontology Molecular function • structural molecule activity • identical protein binding Cellular component • plasma membrane • bicellular tight junction • integral component of membrane Biological process • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules • cell junction assembly • cell-cell junction organization • bicellular tight junction assembly Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	53842	75677
Ensembl	ENSG00000177300	ENSMUSG00000038064
UniProt	Q8N7P3	Q9D7U6
RefSeq (mRNA)	NM_001111319	NM_029383
RefSeq (protein)	NP_001104789	NP_083659
Location (UCSC)	Chr 4: 183.32 – 183.32 Mb	Chr 8: 47.82 – 47.83 Mb
PubMed search

Claudin-22 is a protein that in humans is encoded by the CLDN22 gene.^[1] It belongs to the group of claudins.

References

1. "Entrez Gene: CLDN22 claudin 22".

Further reading

• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins.". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
• Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets.". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
• Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions.". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726.
• Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport.". Traffic 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307.
• Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier.". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502.
• Hillier LW, Graves TA, Fulton RS; et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Katoh M, Katoh M (2004). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family.". Int. J. Mol. Med. 11 (6): 683–9. doi:10.3892/ijmm.11.6.683. PMID 12736707.
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. doi:10.1021/acs.jproteome.5b00769. PMID 26680015.