CLEC11A

C-type lectin domain family 11, member A
Identifiers
Symbols	CLEC11A ; CLECSF3; LSLCL; P47; SCGF
External IDs	OMIM: 604713 MGI: 1298219 HomoloGene: 2236 GeneCards: CLEC11A Gene
Gene ontology Molecular function • growth factor activity • carbohydrate binding Cellular component • extracellular region • extracellular space • cytoplasm Biological process • positive regulation of cell proliferation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6320	20256
Ensembl	ENSG00000105472	ENSMUSG00000004473
UniProt	Q9Y240	O88200
RefSeq (mRNA)	NM_002975	NM_009131
RefSeq (protein)	NP_002966	NP_033157
Location (UCSC)	Chr 19: 50.72 – 50.73 Mb	Chr 7: 44.3 – 44.31 Mb
PubMed search

C-type lectin domain family 11 member A is a protein that in humans is encoded by the CLEC11A gene.^[1][2][3]

This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined.^[3]

References

1. Hiraoka A, Sugimura A, Seki T, Nagasawa T, Ohta N, Shimonishi M, Hagiya M, Shimizu S (Aug 1997). "Cloning, expression, and characterization of a cDNA encoding a novel human growth factor for primitive hematopoietic progenitor cells". Proc Natl Acad Sci U S A 94 (14): 7577–82. doi:10.1073/pnas.94.14.7577. PMC 23864. PMID 9207134.
2. Bannwarth S, Giordanengo V, Lesimple J, Lefebvre JC (Mar 1998). "Molecular cloning of a new secreted sulfated mucin-like protein with a C-type lectin domain that is expressed in lymphoblastic cells". J Biol Chem 273 (4): 1911–6. doi:10.1074/jbc.273.4.1911. PMID 9442024.
3. "Entrez Gene: CLEC11A C-type lectin domain family 11, member A".

Further reading

• Hiraoka A, Ohkubo T, Fukuda M (1987). "Production of human hematopoietic survival and growth factor by a myeloid leukemia cell line (KPB-M15) and placenta as detected by a monoclonal antibody.". Cancer Res. 47 (19): 5025–30. PMID 3304620.
• Mio H, Kagami N, Yokokawa S; et al. (1998). "Isolation and characterization of a cDNA for human mouse, and rat full-length stem cell growth factor, a new member of C-type lectin superfamily.". Biochem. Biophys. Res. Commun. 249 (1): 124–30. doi:10.1006/bbrc.1998.9073. PMID 9705843.
• Bannwarth S, Giordanengo V, Grosgeorge J; et al. (1999). "Cloning, mapping, and genomic organization of the LSLCL gene, encoding a new lymphocytic secreted mucin-like protein with a C-type lectin domain: A new model of exon shuffling.". Genomics 57 (2): 316–7. doi:10.1006/geno.1999.5762. PMID 10198175.
• Gehling UM, Ergün S, Schumacher U; et al. (2000). "In vitro differentiation of endothelial cells from AC133-positive progenitor cells.". Blood 95 (10): 3106–12. PMID 10807776.
• Perrin C, Bayle J, Bannwarth S; et al. (2002). "Expression of LSLCL, a new C-type lectin, is closely restricted, in bone marrow, to immature neutrophils.". C. R. Acad. Sci. III, Sci. Vie 324 (12): 1125–32. doi:10.1016/s0764-4469(01)01392-0. PMID 11803813.
• Hiraoka A, Yano Ki K, Kagami N; et al. (2002). "Stem cell growth factor: in situ hybridization analysis on the gene expression, molecular characterization and in vitro proliferative activity of a recombinant preparation on primitive hematopoietic progenitor cells.". Hematol. J. 2 (5): 307–15. doi:10.1038/sj/thj/6200118. PMID 11920266.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ito C, Sato H, Ando K; et al. (2004). "Serum stem cell growth factor for monitoring hematopoietic recovery following stem cell transplantation.". Bone Marrow Transplant. 32 (4): 391–8. doi:10.1038/sj.bmt.1704152. PMID 12900775.
• Lee E, Min HK, Oskeritzian CA; et al. (2004). "Recombinant human (rh) stem cell factor and rhIL-4 stimulate differentiation and proliferation of CD3+ cells from umbilical cord blood and CD3+ cells enhance FcepsilonR1 expression on fetal liver-derived mast cells in the presence of rhIL-4.". Cell. Immunol. 226 (1): 30–6. doi:10.1016/j.cellimm.2003.11.001. PMID 14746805.
• Hollenbeck ST, Sakakibara K, Faries PL; et al. (2004). "Stem cell factor and c-kit are expressed by and may affect vascular SMCs through an autocrine pathway.". J. Surg. Res. 120 (2): 288–94. doi:10.1016/j.jss.2004.01.005. PMID 15234225.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.