CLEC4A

C-type lectin domain family 4, member A
Identifiers
Symbols	CLEC4A ; CD367; CLECSF6; DCIR; DDB27; HDCGC13P; LLIR
External IDs	OMIM: 605306 MGI: 1349412 HomoloGene: 49291 GeneCards: CLEC4A Gene
Gene ontology Molecular function • transmembrane signaling receptor activity • carbohydrate binding Cellular component • plasma membrane • integral component of plasma membrane Biological process • stimulatory C-type lectin receptor signaling pathway • cell adhesion • cell surface receptor signaling pathway • innate immune response Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	50856	26888
Ensembl	ENSG00000111729	ENSMUSG00000030148
UniProt	Q9UMR7	Q9QZ15
RefSeq (mRNA)	NM_016184	NM_001170332
RefSeq (protein)	NP_057268	NP_001163803
Location (UCSC)	Chr 12: 8.12 – 8.14 Mb	Chr 6: 123.11 – 123.14 Mb
PubMed search

C-type lectin domain family 4 member A is a protein that in humans is encoded by the CLEC4A gene.^[1][2]

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.^[2]

References

1. Bates EE, Fournier N, Garcia E, Valladeau J, Durand I, Pin JJ, Zurawski SM, Patel S, Abrams JS, Lebecque S, Garrone P, Saeland S (Sep 1999). "APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif". J Immunol 163 (4): 1973–83. PMID 10438934.
2. "Entrez Gene: CLEC4A C-type lectin domain family 4, member A".

Further reading

• Drickamer K (1999). "C-type lectin-like domains.". Curr. Opin. Struct. Biol. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3. PMID 10508765.
• Huang X, Yuan Z, Chen G; et al. (2001). "Cloning and characterization of a novel ITIM containing lectin-like immunoreceptor LLIR and its two transmembrane region deletion variants.". Biochem. Biophys. Res. Commun. 281 (1): 131–40. doi:10.1006/bbrc.2001.4322. PMID 11178971.
• Richard M, Veilleux P, Rouleau M; et al. (2002). "The expression pattern of the ITIM-bearing lectin CLECSF6 in neutrophils suggests a key role in the control of inflammation.". J. Leukoc. Biol. 71 (5): 871–80. PMID 11994513.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily.". Proteins 53 (1): 44–55. doi:10.1002/prot.10440. PMID 12945048.
• Richard M, Thibault N, Veilleux P; et al. (2003). "The ITIM-bearing CLECSF6 (DCIR) is down-modulated in neutrophils by neutrophil activating agents.". Biochem. Biophys. Res. Commun. 310 (3): 767–73. doi:10.1016/j.bbrc.2003.09.077. PMID 14550269.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Richard M, Thibault N, Veilleux P; et al. (2006). "Granulocyte macrophage-colony stimulating factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils: a new mechanism of action for SHP-2.". Mol. Immunol. 43 (10): 1716–21. doi:10.1016/j.molimm.2005.10.006. PMID 16360206.
• Lorentzen JC, Flornes L, Eklöw C; et al. (2007). "Association of arthritis with a gene complex encoding C-type lectin-like receptors.". Arthritis Rheum. 56 (8): 2620–32. doi:10.1002/art.22813. PMID 17665455.