CLEC5A

C-type lectin domain family 5, member A
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2YHF
Identifiers
Symbols	CLEC5A ; CLECSF5; MDL-1; MDL1
External IDs	OMIM: 604987 MGI: 1345151 HomoloGene: 8302 GeneCards: CLEC5A Gene
Gene ontology Molecular function • virus receptor activity • carbohydrate binding Cellular component • plasma membrane • integral component of plasma membrane • cell surface Biological process • osteoblast development • cellular defense response • signal transduction • myeloid cell differentiation • negative regulation of myeloid cell apoptotic process • negative regulation of apoptotic process • innate immune response • viral entry into host cell • positive regulation of cytokine secretion Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23601	23845
Ensembl	ENSG00000258227	ENSMUSG00000029915
UniProt	Q9NY25	Q9R007
RefSeq (mRNA)	NM_001301167	NM_001038604
RefSeq (protein)	NP_001288096	NP_001033693
Location (UCSC)	Chr 7: 141.93 – 141.95 Mb	Chr 6: 40.57 – 40.59 Mb
PubMed search

C-type lectin domain family 5 member A or CLEC5A, also known as C-type lectin superfamily member 5 (CLECSF5) and myeloid DAP12-associating lectin 1 (MDL1) is a C-type lectin that in humans is encoded by the CLEC5A gene.^[1][2] It appears to be a member of a significant myeloid lineage activating pathway.

References

1. "Entrez Gene: C-type lectin domain family 5".
2. Bakker AB, Baker E, Sutherland GR, Phillips JH, Lanier LL (August 1999). "Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9792–6. doi:10.1073/pnas.96.17.9792. PMC 22289. PMID 10449773.

Further reading

• Joyce-Shaikh B; et al. (2010). "Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis.". J Exp Med. 207 (3): 579–89. doi:10.1084/jem.20090516. PMID 20090516.
• Chen ST, Lin YL, Huang MT; et al. (2008). "CLEC5A is critical for dengue-virus-induced lethal disease.". Nature 453 (7195): 672–6. doi:10.1038/nature07013. PMID 18496526.
• Davila S, Froeling FE, Tan A; et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine.". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
• Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily.". Proteins 53 (1): 44–55. doi:10.1002/prot.10440. PMID 12945048.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Drickamer K (1999). "C-type lectin-like domains.". Curr. Opin. Struct. Biol. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3. PMID 10508765.
• Watson AA, O'Callaghan CA (2010). "Crystallization and X-ray diffraction analysis of human CLEC5A (MDL-1), a dengue virus receptor.". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (Pt 1): 29–31. doi:10.1107/S1744309109047915. PMC 2805530. PMID 20057064.