CLIP1

CAP-GLY domain containing linker protein 1
PDB rendering based on 2cp5.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2CP5​, 2CP6​, 2E3H​, 2E3I​, 2E4H​, 2HQH​, 2QK0​, 3E2U​, 3RDV​
Identifiers
Symbols	CLIP1 ; CLIP; CLIP-170; CLIP170; CYLN1; RSN
External IDs	OMIM: 179838 MGI: 1928401 HomoloGene: 74455 GeneCards: CLIP1 Gene
Gene ontology Molecular function • nucleic acid binding • protein binding • microtubule binding • zinc ion binding • tubulin binding • protein homodimerization activity • metal ion binding • microtubule plus-end binding Cellular component • kinetochore • ruffle • cytoplasm • endosome • centrosome • cytosol • microtubule • cytoplasmic microtubule • intermediate filament • microtubule cytoskeleton • cytoplasmic vesicle membrane • microtubule plus-end • macropinosome Biological process • mitotic cell cycle • microtubule bundle formation • mitotic nuclear division • small GTPase mediated signal transduction • positive regulation of microtubule polymerization • protein transport into plasma membrane raft Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6249	56430
Ensembl	ENSG00000130779	ENSMUSG00000049550
UniProt	P30622	Q922J3
RefSeq (mRNA)	NM_001247997	NM_001291229
RefSeq (protein)	NP_001234926	NP_001278158
Location (UCSC)	Chr 12: 122.27 – 122.42 Mb	Chr 5: 123.58 – 123.68 Mb
PubMed search

CAP-GLY domain containing linker protein 1, also known as CLIP1, is a protein which in humans is encoded by the CLIP1 gene.^[1]

Interactions

CLIP1 has been shown to interact with IQGAP1,^[2] Mammalian target of rapamycin^[3] and PAFAH1B1.^[4]

References

1. "Entrez Gene: CLIP1 CAP-GLY domain containing linker protein 1".
2. Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, Matsuura Y, Iwamatsu A, Perez F, Kaibuchi K (Jun 2002). "Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170". Cell 109 (7): 873–85. doi:10.1016/S0092-8674(02)00800-0. PMID 12110184.
3. Choi JH, Bertram PG, Drenan R, Carvalho J, Zhou HH, Zheng XF (Oct 2002). "The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase". EMBO Reports 3 (10): 988–94. doi:10.1093/embo-reports/kvf197. PMC 1307618. PMID 12231510.
4. Coquelle FM, Caspi M, Cordelières FP, Dompierre JP, Dujardin DL, Koifman C, Martin P, Hoogenraad CC, Akhmanova A, Galjart N, De Mey JR, Reiner O (May 2002). "LIS1, CLIP-170's key to the dynein/dynactin pathway". Molecular and Cellular Biology 22 (9): 3089–102. doi:10.1128/MCB.22.9.3089-3102.2002. PMC 133759. PMID 11940666.

Further reading

• Galjart N (Jun 2005). "CLIPs and CLASPs and cellular dynamics". Nature Reviews Molecular Cell Biology 6 (6): 487–98. doi:10.1038/nrm1664. PMID 15928712.
• Pierre P, Scheel J, Rickard JE, Kreis TE (Sep 1992). "CLIP-170 links endocytic vesicles to microtubules". Cell 70 (6): 887–900. doi:10.1016/0092-8674(92)90240-D. PMID 1356075.
• Bilbe G, Delabie J, Brüggen J, Richener H, Asselbergs FA, Cerletti N, Sorg C, Odink K, Tarcsay L, Wiesendanger W (Jun 1992). "Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease". The EMBO Journal 11 (6): 2103–13. PMC 556677. PMID 1600942.
• Pierre P, Pepperkok R, Kreis TE (Jul 1994). "Molecular characterization of two functional domains of CLIP-170 in vivo". Journal of Cell Science 107 (7): 1909–20. PMID 7983157.
• Hilliker C, Delabie J, Speleman F, Bilbe G, Bruggen J, Van Leuven F, Van den Berghe H (1993). "Localization of the gene (RSN) coding for restin, a marker for Reed-Sternberg cells in Hodgkin's disease, to human chromosome band 12q24.3 and YAC cloning of the locus". Cytogenetics and Cell Genetics 65 (3): 172–6. doi:10.1159/000133625. PMID 8222754.
• Griparic L, Keller TC (Oct 1998). "Identification and expression of two novel CLIP-170/Restin isoforms expressed predominantly in muscle". Biochimica et Biophysica Acta 1405 (1-3): 35–46. doi:10.1016/S0167-4889(98)00096-2. PMID 9784600.
• Perez F, Diamantopoulos GS, Stalder R, Kreis TE (Feb 1999). "CLIP-170 highlights growing microtubule ends in vivo". Cell 96 (4): 517–27. doi:10.1016/S0092-8674(00)80656-X. PMID 10052454.
• Akhmanova A, Hoogenraad CC, Drabek K, Stepanova T, Dortland B, Verkerk T, Vermeulen W, Burgering BM, De Zeeuw CI, Grosveld F, Galjart N (Mar 2001). "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts". Cell 104 (6): 923–35. doi:10.1016/S0092-8674(01)00288-4. PMID 11290329.
• Coquelle FM, Caspi M, Cordelières FP, Dompierre JP, Dujardin DL, Koifman C, Martin P, Hoogenraad CC, Akhmanova A, Galjart N, De Mey JR, Reiner O (May 2002). "LIS1, CLIP-170's key to the dynein/dynactin pathway". Molecular and Cellular Biology 22 (9): 3089–102. doi:10.1128/MCB.22.9.3089-3102.2002. PMC 133759. PMID 11940666.
• Griffith KJ, Ryan JP, Senécal JL, Fritzler MJ (Mar 2002). "The cytoplasmic linker protein CLIP-170 is a human autoantigen". Clinical and Experimental Immunology 127 (3): 533–8. doi:10.1046/j.1365-2249.2002.01756.x. PMC 1906301. PMID 11966772.
• Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, Matsuura Y, Iwamatsu A, Perez F, Kaibuchi K (Jun 2002). "Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170". Cell 109 (7): 873–85. doi:10.1016/S0092-8674(02)00800-0. PMID 12110184.
• Choi JH, Bertram PG, Drenan R, Carvalho J, Zhou HH, Zheng XF (Oct 2002). "The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase". EMBO Reports 3 (10): 988–94. doi:10.1093/embo-reports/kvf197. PMC 1307618. PMID 12231510.
• Sahin U, Neumann F, Tureci O, Schmits R, Perez F, Pfreundschuh M (Dec 2002). "Hodgkin and Reed-Sternberg cell-associated autoantigen CLIP-170/restin is a marker for dendritic cells and is involved in the trafficking of macropinosomes to the cytoskeleton, supporting a function-based concept of Hodgkin and Reed-Sternberg cells". Blood 100 (12): 4139–45. doi:10.1182/blood.V100.12.4139. PMID 12433698.
• Goodson HV, Skube SB, Stalder R, Valetti C, Kreis TE, Morrison EE, Schroer TA (Jul 2003). "CLIP-170 interacts with dynactin complex and the APC-binding protein EB1 by different mechanisms". Cell Motility and the Cytoskeleton 55 (3): 156–73. doi:10.1002/cm.10114. PMID 12789661.
• Ho SM, Lau KM, Mok SC, Syed V (Jul 2003). "Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells". Oncogene 22 (27): 4243–56. doi:10.1038/sj.onc.1206437. PMID 12833147.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (Nov 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Watanabe T, Wang S, Noritake J, Sato K, Fukata M, Takefuji M, Nakagawa M, Izumi N, Akiyama T, Kaibuchi K (Dec 2004). "Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration". Developmental Cell 7 (6): 871–83. doi:10.1016/j.devcel.2004.10.017. PMID 15572129.