CLSTN1

Calsyntenin 1
Identifiers
Symbols	CLSTN1 ; ALC-ALPHA; CDHR12; CST-1; CSTN1; PIK3CD; XB31alpha; alcalpha1; alcalpha2
External IDs	OMIM: 611321 MGI: 1929895 HomoloGene: 8814 GeneCards: CLSTN1 Gene
Gene ontology Molecular function • beta-amyloid binding • calcium ion binding • protein binding • kinesin binding • X11-like protein binding Cellular component • Golgi membrane • nucleus • endoplasmic reticulum membrane • cell surface • integral component of membrane • cell junction • postsynaptic membrane • extracellular exosome • neuronal postsynaptic density Biological process • regulation of cell growth • cell adhesion • homophilic cell adhesion via plasma membrane adhesion molecules • positive regulation of synaptic transmission • positive regulation of synapse assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22883	65945
Ensembl	ENSG00000171603	ENSMUSG00000039953
UniProt	O94985	Q9EPL2
RefSeq (mRNA)	NM_001009566	NM_001290989
RefSeq (protein)	NP_001009566	NP_001277918
Location (UCSC)	Chr 1: 9.73 – 9.82 Mb	Chr 4: 149.59 – 149.65 Mb
PubMed search

Calsyntenin-1 is a protein that in humans is encoded by the CLSTN1 gene.^[1][2]

Clinical relevance

Mutations in this gene have been shown associated to pathogenic mechanisms of Alzheimer's disease.^[3]

Interactions

CLSTN1 has been shown to interact with APBA2^[4][5] and Amyloid precursor protein.^[4][5]

References

1. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
2. "Entrez Gene: CLSTN1 calsyntenin 1".
3. Vagnoni A, Perkinton MS, Gray EH, Francis PT, Noble W, Miller CC (Jul 2012). "Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production". Human Molecular Genetics 21 (13): 2845–54. doi:10.1093/hmg/dds109. PMID 22434822.
4. Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T (Dec 2003). "Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism". The Journal of Biological Chemistry 278 (49): 49448–58. doi:10.1074/jbc.M306024200. PMID 12972431.
5. Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T (Jun 2004). "Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation". The Journal of Biological Chemistry 279 (23): 24343–54. doi:10.1074/jbc.M401925200. PMID 15037614.

Further reading

• Konecna A, Frischknecht R, Kinter J, Ludwig A, Steuble M, Meskenaite V, Indermühle M, Engel M, Cen C, Mateos JM, Streit P, Sonderegger P (Aug 2006). "Calsyntenin-1 docks vesicular cargo to kinesin-1". Molecular Biology of the Cell 17 (8): 3651–63. doi:10.1091/mbc.E06-02-0112. PMC 1525238. PMID 16760430.
• Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, Cohen FE, Prusiner SB, Baldwin MA (Jun 2004). "Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues". Nature Biotechnology 22 (6): 724–31. doi:10.1038/nbt969. PMID 15146195.
• Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T (Jun 2004). "Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation". The Journal of Biological Chemistry 279 (23): 24343–54. doi:10.1074/jbc.M401925200. PMID 15037614.
• Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T (Dec 2003). "Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism". The Journal of Biological Chemistry 278 (49): 49448–58. doi:10.1074/jbc.M306024200. PMID 12972431.
• Nakayama M, Kikuno R, Ohara O (Nov 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Vogt L, Schrimpf SP, Meskenaite V, Frischknecht R, Kinter J, Leone DP, Ziegler U, Sonderegger P (Jan 2001). "Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain". Molecular and Cellular Neurosciences 17 (1): 151–66. doi:10.1006/mcne.2000.0937. PMID 11161476.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.