CNOT3

CCR4-NOT transcription complex, subunit 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4C0D​, 4C0G​
Identifiers
Symbols	CNOT3 ; LENG2; NOT3; NOT3H
External IDs	OMIM: 604910 MGI: 2385261 HomoloGene: 133900 GeneCards: CNOT3 Gene
Gene ontology Molecular function • protein binding Cellular component • cytoplasmic mRNA processing body • nucleus • cytosol • CCR4-NOT complex Biological process • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • nuclear-transcribed mRNA poly(A) tail shortening • trophectodermal cell differentiation • transcription, DNA-templated • regulation of transcription, DNA-templated • regulation of translation • gene expression • gene silencing by RNA • regulation of stem cell maintenance Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4849	232791
Ensembl	ENSG00000088038	ENSMUSG00000035632
UniProt	O75175	Q8K0V4
RefSeq (mRNA)	NM_014516	NM_146176
RefSeq (protein)	NP_055331	NP_666288
Location (UCSC)	Chr 19: 54.14 – 54.16 Mb	Chr 7: 3.65 – 3.66 Mb
PubMed search

CCR4-NOT transcription complex subunit 3 is a protein that in humans is encoded by the CNOT3 gene.^[1][2][3]

Interactions

CNOT3 has been shown to interact with CNOT8.^[1]

References

1. Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (Mar 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.
2. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
3. "Entrez Gene: CNOT3 CCR4-NOT transcription complex, subunit 3".

Further reading

• Wende H, Volz A, Ziegler A (2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics 51 (8-9): 703–13. doi:10.1007/s002510000187. PMID 10941842.
• Aoki T, Okada N, Wakamatsu T, Tamura TA (2002). "TBP-interacting protein 120B, which is induced in relation to myogenesis, binds to NOT3". Biochem. Biophys. Res. Commun. 296 (5): 1097–103. doi:10.1016/S0006-291X(02)02031-4. PMID 12207886.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Yin X, Warner DR, Roberts EA, Pisano MM, Greene RM (2005). "Identification of novel CBP interacting proteins in embryonic orofacial tissue". Biochem. Biophys. Res. Commun. 329 (3): 1010–7. doi:10.1016/j.bbrc.2005.02.075. PMID 15752756.