CNOT6

CCR4-NOT transcription complex, subunit 6
Identifiers
Symbols	CNOT6 ; CCR4; Ccr4a
External IDs	OMIM: 608951 MGI: 2144529 HomoloGene: 69187 GeneCards: CNOT6 Gene
EC number	3.1.13.4
Gene ontology Molecular function • RNA binding • exoribonuclease activity • poly(A)-specific ribonuclease activity • protein binding • metal ion binding Cellular component • nucleus • cytosol • membrane • CCR4-NOT complex Biological process • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • nuclear-transcribed mRNA poly(A) tail shortening • transcription, DNA-templated • regulation of transcription, DNA-templated • regulation of translation • positive regulation of cell proliferation • gene expression • positive regulation of cytoplasmic mRNA processing body assembly • gene silencing by miRNA • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay • nuclear-transcribed mRNA catabolic process, no-go decay • RNA phosphodiester bond hydrolysis, exonucleolytic • positive regulation of ligand-dependent nuclear receptor transcription coactivator activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57472	104625
Ensembl	ENSG00000113300	ENSMUSG00000020362
UniProt	Q9ULM6	Q8K3P5
RefSeq (mRNA)	NM_001303241	NM_001290741
RefSeq (protein)	NP_001290170	NP_001277670
Location (UCSC)	Chr 5: 180.49 – 180.58 Mb	Chr 11: 49.67 – 49.71 Mb
PubMed search

CCR4-NOT transcription complex subunit 6 is a protein that in humans is encoded by the CNOT6 gene.^[1][2]

The protein encoded by this gene is a subunit of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substates.^[2]

References

1. Chen J, Chiang YC, Denis CL (Mar 2002). "CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase". EMBO J 21 (6): 1414–26. doi:10.1093/emboj/21.6.1414. PMC 125924. PMID 11889047.
2. "Entrez Gene: CNOT6 CCR4-NOT transcription complex, subunit 6".

Further reading

• Okubo K, Itoh K, Fukushima A; et al. (1996). "Monitoring cell physiology by expression profiles and discovering cell type-specific genes by compiled expression profiles.". Genomics 30 (2): 178–86. doi:10.1006/geno.1995.9887. PMID 8586417.
• Nagase T, Ishikawa K, Kikuno R; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
• Albert TK, Lemaire M, van Berkum NL; et al. (2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.
• Dupressoir A, Morel AP, Barbot W; et al. (2003). "Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding.". BMC Genomics 2: 9. doi:10.1186/1471-2164-2-9. PMC 61044. PMID 11747467.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Chang TC, Yamashita A, Chen CY; et al. (2004). "UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant.". Genes Dev. 18 (16): 2010–23. doi:10.1101/gad.1219104. PMC 514181. PMID 15314026.
• Oh JH, Yang JO, Hahn Y; et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.