CNOT7

CCR4-NOT transcription complex, subunit 7

PDB rendering based on 2d5r.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CNOT7 ; CAF1; Caf1a; hCAF-1
External IDs OMIM: 604913 MGI: 1298230 HomoloGene: 49011 GeneCards: CNOT7 Gene
EC number 3.1.13.4
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 29883 18983
Ensembl ENSG00000198791 ENSMUSG00000031601
UniProt Q9UIV1 Q60809
RefSeq (mRNA) NM_013354 NM_001271542
RefSeq (protein) NP_037486 NP_001258471
Location (UCSC) Chr 8:
17.22 – 17.25 Mb
Chr 8:
40.49 – 40.52 Mb
PubMed search

CCR4-NOT transcription complex subunit 7 is a protein that in humans is encoded by the CNOT7 gene.[1][2][3][4]

Function

The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms.[4]

Interactions

CNOT7 has been shown to interact with:

References

  1. Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (March 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.
  2. Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC (March 1992). "Sequence identification of 2,375 human brain genes". Nature 355 (6361): 632–4. doi:10.1038/355632a0. PMID 1538749.
  3. Robin-Lespinasse Y, Sentis S, Kolytcheff C, Rostan MC, Corbo L, Le Romancer M (February 2007). "hCAF1, a new regulator of PRMT1-dependent arginine methylation". J. Cell. Sci. 120 (Pt 4): 638–47. doi:10.1242/jcs.03357. PMID 17264152.
  4. 1 2 "Entrez Gene: CNOT7 CCR4-NOT transcription complex, subunit 7".
  5. Bogdan JA, Adams-Burton C, Pedicord DL, Sukovich DA, Benfield PA, Corjay MH, Stoltenborg JK, Dicker IB (December 1998). "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1". Biochem. J. 336 ( Pt 2): 471–81. PMC 1219893. PMID 9820826.
  6. Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, Corbo L (March 2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. 276 (13): 9640–8. doi:10.1074/jbc.M008201200. PMID 11136725.
  7. 1 2 Funakoshi Y, Doi Y, Hosoda N, Uchida N, Osawa M, Shimada I, Tsujimoto M, Suzuki T, Katada T, Hoshino S (December 2007). "Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases". Genes Dev. 21 (23): 3135–48. doi:10.1101/gad.1597707. PMC 2081979. PMID 18056425.
  8. 1 2 Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T (December 1999). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". Oncogene 18 (52): 7432–41. doi:10.1038/sj.onc.1203193. PMID 10602502.

Further reading


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