CNTN2

Contactin 2 (axonal)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2OM5​
Identifiers
Symbols	CNTN2 ; AXT; FAME5; TAG-1; TAX; TAX1
External IDs	OMIM: 190197 MGI: 104518 HomoloGene: 3720 GeneCards: CNTN2 Gene
Gene ontology Molecular function • glycoprotein binding • carbohydrate binding • identical protein binding • protein self-association Cellular component • plasma membrane • integral component of plasma membrane • voltage-gated potassium channel complex • cell surface • anchored component of membrane • node of Ranvier • neuronal cell body • myelin sheath • juxtaparanode region of axon • synapse Biological process • microtubule cytoskeleton organization • cell adhesion • cell-matrix adhesion • axon guidance • axonal fasciculation • learning • adult walking behavior • positive regulation of protein processing • cerebral cortex GABAergic interneuron migration • central nervous system myelination • regulation of axon diameter • receptor internalization • clustering of voltage-gated potassium channels • negative regulation of neuron differentiation • regulation of neuronal synaptic plasticity • regulation of astrocyte differentiation • positive regulation of adenosine receptor signaling pathway • protein localization to juxtaparanode region of axon • establishment of protein localization to juxtaparanode region of axon • presynaptic membrane organization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6900	21367
Ensembl	ENSG00000184144	ENSMUSG00000053024
UniProt	Q02246	Q61330
RefSeq (mRNA)	NM_005076	NM_011531
RefSeq (protein)	NP_005067	NP_796103
Location (UCSC)	Chr 1: 205.04 – 205.08 Mb	Chr 1: 132.51 – 132.54 Mb
PubMed search

Contactin-2 is a protein that in humans is encoded by the CNTN2 gene.^[1][2][3]

Function

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention.^[3]

Interactions

CNTN2 has been shown to interact with CNTNAP2^[4] and NFYB.^[5]

References

1. Tsiotra PC, Karagogeos D, Theodorakis K, Michaelidis TM, Modi WS, Furley AJ, Jessell TM, Papamatheakis J (Dec 1993). "Isolation of the cDNA and chromosomal localization of the gene (TAX1) encoding the human axonal glycoprotein TAG-1". Genomics 18 (3): 562–7. doi:10.1016/S0888-7543(05)80357-X. PMID 8307567.
2. Yoshihara Y, Kawasaki M, Tamada A, Nagata S, Kagamiyama H, Mori K (Sep 1995). "Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily". Journal of Neurobiology 28 (1): 51–69. doi:10.1002/neu.480280106. PMID 8586965.
3. "Entrez Gene: CNTN2 contactin 2 (axonal)".
4. Traka M, Goutebroze L, Denisenko N, Bessa M, Nifli A, Havaki S, Iwakura Y, Fukamauchi F, Watanabe K, Soliven B, Girault JA, Karagogeos D (Sep 2003). "Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers". The Journal of Cell Biology 162 (6): 1161–72. doi:10.1083/jcb.200305078. PMC 2172849. PMID 12975355.
5. Pise-Masison CA, Dittmer J, Clemens KE, Brady JN (Mar 1997). "Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y". Molecular and Cellular Biology 17 (3): 1236–43. doi:10.1128/mcb.17.3.1236. PMC 231848. PMID 9032250.

Further reading

• Walsh FS, Doherty P (Nov 1991). "Glycosylphosphatidylinositol anchored recognition molecules that function in axonal fasciculation, growth and guidance in the nervous system". Cell Biology International Reports 15 (11): 1151–66. doi:10.1016/0309-1651(91)90061-M. PMID 1838307.
• Kuhn TB, Stoeckli ET, Condrau MA, Rathjen FG, Sonderegger P (Nov 1991). "Neurite outgrowth on immobilized axonin-1 is mediated by a heterophilic interaction with L1(G4)". The Journal of Cell Biology 115 (4): 1113–26. doi:10.1083/jcb.115.4.1113. PMC 2289947. PMID 1720120.
• Dodd J, Morton SB, Karagogeos D, Yamamoto M, Jessell TM (Apr 1988). "Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons". Neuron 1 (2): 105–16. doi:10.1016/0896-6273(88)90194-8. PMID 3272160.
• Kenwrick S, Leversha M, Rooke L, Hasler T, Sonderegger P (Sep 1993). "Localization of the human TAX-1 gene to 1q32.1: a region implicated in microcephaly and Van der Woude syndrome". Human Molecular Genetics 2 (9): 1461–2. doi:10.1093/hmg/2.9.1461. PMID 8242070.
• Rader C, Stoeckli ET, Ziegler U, Osterwalder T, Kunz B, Sonderegger P (Jul 1993). "Cell-cell adhesion by homophilic interaction of the neuronal recognition molecule axonin-1". European Journal of Biochemistry / FEBS 215 (1): 133–41. doi:10.1111/j.1432-1033.1993.tb18015.x. PMID 8344273.
• Hasler TH, Rader C, Stoeckli ET, Zuellig RA, Sonderegger P (Jan 1993). "cDNA cloning, structural features, and eucaryotic expression of human TAG-1/axonin-1". European Journal of Biochemistry / FEBS 211 (1-2): 329–39. doi:10.1111/j.1432-1033.1993.tb19902.x. PMID 8425542.
• Kozlov SV, Giger RJ, Hasler T, Korvatska E, Schorderet DF, Sonderegger P (Nov 1995). "The human TAX1 gene encoding the axon-associated cell adhesion molecule TAG-1/axonin-1: genomic structure and basic promoter". Genomics 30 (2): 141–8. doi:10.1006/geno.1995.9892. PMID 8586412.
• Milev P, Maurel P, Häring M, Margolis RK, Margolis RU (Jun 1996). "TAG-1/axonin-1 is a high-affinity ligand of neurocan, phosphacan/protein-tyrosine phosphatase-zeta/beta, and N-CAM". The Journal of Biological Chemistry 271 (26): 15716–23. doi:10.1074/jbc.271.26.15716. PMID 8663515.
• Pise-Masison CA, Dittmer J, Clemens KE, Brady JN (Mar 1997). "Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y". Molecular and Cellular Biology 17 (3): 1236–43. doi:10.1128/mcb.17.3.1236. PMC 231848. PMID 9032250.
• Williams H, Schachner M, Wang B, Kenwrick S (Nov 1997). "Radiation hybrid mapping of the genes for tenascin-R (TNR), phosducin (PDC), laminin C1 (LAMC1), and TAX in 1q25-q32". Genomics 46 (1): 165–6. doi:10.1006/geno.1997.4994. PMID 9403076.
• Malhotra JD, Tsiotra P, Karagogeos D, Hortsch M (Dec 1998). "Cis-activation of L1-mediated ankyrin recruitment by TAG-1 homophilic cell adhesion". The Journal of Biological Chemistry 273 (50): 33354–9. doi:10.1074/jbc.273.50.33354. PMID 9837910.
• Freigang J, Proba K, Leder L, Diederichs K, Sonderegger P, Welte W (May 2000). "The crystal structure of the ligand binding module of axonin-1/TAG-1 suggests a zipper mechanism for neural cell adhesion". Cell 101 (4): 425–33. doi:10.1016/S0092-8674(00)80852-1. PMID 10830169.
• Rickman DS, Tyagi R, Zhu XX, Bobek MP, Song S, Blaivas M, Misek DE, Israel MA, Kurnit DM, Ross DA, Kish PE, Hanash SM (Mar 2001). "The gene for the axonal cell adhesion molecule TAX-1 is amplified and aberrantly expressed in malignant gliomas". Cancer Research 61 (5): 2162–8. PMID 11280781.
• Pavlou O, Theodorakis K, Falk J, Kutsche M, Schachner M, Faivre-Sarrailh C, Karagogeos D (Jul 2002). "Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members". Molecular and Cellular Neurosciences 20 (3): 367–81. doi:10.1006/mcne.2002.1105. PMID 12139915.
• Traka M, Goutebroze L, Denisenko N, Bessa M, Nifli A, Havaki S, Iwakura Y, Fukamauchi F, Watanabe K, Soliven B, Girault JA, Karagogeos D (Sep 2003). "Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers". The Journal of Cell Biology 162 (6): 1161–72. doi:10.1083/jcb.200305078. PMC 2172849. PMID 12975355.
• Nagaraja GM, Kandpal RP (Jan 2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins". Biochemical and Biophysical Research Communications 313 (3): 654–65. doi:10.1016/j.bbrc.2003.12.001. PMID 14697242.