CNTNAP4

Contactin associated protein-like 4
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4NXQ​
Identifiers
Symbols	CNTNAP4 ; CASPR4
External IDs	OMIM: 610518 MGI: 2183572 HomoloGene: 24912 GeneCards: CNTNAP4 Gene
Gene ontology Molecular function • receptor binding Cellular component • integral component of membrane • cell junction • dendrite • presynaptic membrane Biological process • cell adhesion • regulation of synaptic transmission, dopaminergic • regulation of synaptic transmission, GABAergic • regulation of grooming behavior Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	85445	170571
Ensembl	ENSG00000152910	ENSMUSG00000031772
UniProt	Q9C0A0	Q99P47
RefSeq (mRNA)	NM_033401	NM_130457
RefSeq (protein)	NP_207837	NP_569724
Location (UCSC)	Chr 16: 76.28 – 76.56 Mb	Chr 8: 112.57 – 112.88 Mb
PubMed search

Contactin-associated protein-like 4 is a protein that in humans is encoded by the CNTNAP4 gene.^[1][2]

This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. Alternative splicing results in two transcript variants encoding different isoforms.^[2]

References

1. Spiegel I, Salomon D, Erne B, Schaeren-Wiemers N, Peles E (Jul 2002). "Caspr3 and caspr4, two novel members of the caspr family are expressed in the nervous system and interact with PDZ domains". Mol Cell Neurosci 20 (2): 283–97. doi:10.1006/mcne.2002.1110. PMID 12093160.
2. "Entrez Gene: CNTNAP4 contactin associated protein-like 4".

Further reading

• Kim JM, Lee KH, Jeon YJ; et al. (2007). "Identification of genes related to Parkinson's disease using expressed sequence tags". DNA Res. 13 (6): 275–86. doi:10.1093/dnares/dsl016. PMID 17213182.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Nagase T, Kikuno R, Hattori A; et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
• Auffray C, Behar G, Bois F; et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". C. R. Acad. Sci. III, Sci. Vie 318 (2): 263–72. PMID 7757816.