COASY

CoA synthase
Identifiers
Symbols	COASY ; DPCK; NBIA6; NBP; PPAT; UKR1; pOV-2
External IDs	OMIM: 609855 MGI: 1918993 HomoloGene: 11889 GeneCards: COASY Gene
EC number	2.7.1.24, 2.7.7.3
Gene ontology Molecular function • dephospho-CoA kinase activity • pantetheine-phosphate adenylyltransferase activity • protein binding • ATP binding Cellular component • nucleoplasm • cytoplasm • mitochondrial outer membrane • mitochondrial matrix • extracellular exosome Biological process • vitamin metabolic process • water-soluble vitamin metabolic process • coenzyme biosynthetic process • coenzyme A biosynthetic process • pantothenate metabolic process • phosphorylation • small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	80347	71743
Ensembl	ENSG00000068120	ENSMUSG00000001755
UniProt	Q13057	Q9DBL7
RefSeq (mRNA)	NM_001042529	NM_001305982
RefSeq (protein)	NP_001035994	NP_001292911
Location (UCSC)	Chr 17: 42.56 – 42.57 Mb	Chr 11: 101.08 – 101.09 Mb
PubMed search

Bifunctional coenzyme A synthase is an enzyme that in humans is encoded by the COASY gene.^[1][2][3]

Interactions

COASY has been shown to interact with P70-S6 Kinase 1.^[4] In 2009, COASY has also been implicated in PI3K signaling, as it was shown to interact with a regulatory subunit of PI3K.^[5]

References

1. Daugherty M, Polanuyer B, Farrell M, Scholle M, Lykidis A, de Crecy-Lagard V, Osterman A (Jun 2002). "Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics". J Biol Chem 277 (24): 21431–9. doi:10.1074/jbc.M201708200. PMID 11923312.
2. Zhyvoloup A, Nemazanyy I, Babich A, Panasyuk G, Pobigailo N, Vudmaska M, Naidenov V, Kukharenko O, Palchevskii S, Savinska L, Ovcharenko G, Verdier F, Valovka T, Fenton T, Rebholz H, Wang ML, Shepherd P, Matsuka G, Filonenko V, Gout IT (Jun 2002). "Molecular cloning of CoA Synthase. The missing link in CoA biosynthesis". J Biol Chem 277 (25): 22107–10. doi:10.1074/jbc.C200195200. PMID 11980892.
3. "Entrez Gene: COASY Coenzyme A synthase".
4. Nemazanyy, Ivan; Panasyuk Ganna; Zhyvoloup Alexander; Panayotou George; Gout Ivan T; Filonenko Valeriy (Dec 2004). "Specific interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolism". FEBS Lett. (Netherlands) 578 (3): 357–62. doi:10.1016/j.febslet.2004.10.091. ISSN 0014-5793. PMID 15589845.
5. Breus, Oksana; Panasyuk G; Gout IT; Filonenko V; Nemazanyy I (May 2009). "CoA synthase is in complex with p85alphaPI3K and affects PI3K signaling pathway.". Biochem Biophys Res Commun. 385 (4): 581–5. doi:10.1016/j.bbrc.2009.05.102. PMID 19482007.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Montagna M, Serova O, Sylla BS; et al. (1996). "A 100-kb physical and transcriptional map around the EDH17B2 gene: identification of three novel genes and a pseudogene of a human homologue of the rat PRL-1 tyrosine phosphatase". Hum. Genet. 96 (5): 532–8. doi:10.1007/bf00197407. PMID 8529999.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Aghajanian S, Worrall DM (2002). "Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase)". Biochem. J. 365 (Pt 1): 13–8. doi:10.1042/BJ20020569. PMC 1222654. PMID 11994049.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhyvoloup A, Nemazanyy I, Panasyuk G; et al. (2004). "Subcellular localization and regulation of coenzyme A synthase". J. Biol. Chem. 278 (50): 50316–21. doi:10.1074/jbc.M307763200. PMID 14514684.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nemazanyy I, Panasyuk G, Zhyvoloup A; et al. (2005). "Specific interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolism". FEBS Lett. 578 (3): 357–62. doi:10.1016/j.febslet.2004.10.091. PMID 15589845.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Oh JH, Yang JO, Hahn Y; et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Nemazanyy I, Panasyuk G, Breus O; et al. (2006). "Identification of a novel CoA synthase isoform, which is primarily expressed in the brain". Biochem. Biophys. Res. Commun. 341 (4): 995–1000. doi:10.1016/j.bbrc.2006.01.051. PMID 16460672.