COG1
| Component of oligomeric golgi complex 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | COG1 ; CDG2G; LDLB | ||||||||||||
| External IDs | OMIM: 606973 MGI: 1333873 HomoloGene: 8411 GeneCards: COG1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9382 | 16834 | |||||||||||
| Ensembl | ENSG00000166685 | ENSMUSG00000018661 | |||||||||||
| UniProt | Q8WTW3 | Q9Z160 | |||||||||||
| RefSeq (mRNA) | NM_018714 | NM_013581 | |||||||||||
| RefSeq (protein) | NP_061184 | NP_038609 | |||||||||||
| Location (UCSC) |
Chr 17: 73.19 – 73.21 Mb |
Chr 11: 113.65 – 113.67 Mb | |||||||||||
| PubMed search | |||||||||||||
Conserved oligomeric Golgi complex subunit 1 is a protein that in humans is encoded by the COG1 gene.[1][2]
The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex.[2]
Interactions
COG1 has been shown to interact with COG4[3] and COG3.[4]
References
- ↑ Chatterton JE, Hirsch D, Schwartz JJ, Bickel PE, Rosenberg RD, Lodish HF, Krieger M (Mar 1999). "Expression cloning of LDLB, a gene essential for normal Golgi function and assembly of the ldlCp complex". Proc Natl Acad Sci U S A 96 (3): 915–20. doi:10.1073/pnas.96.3.915. PMC 15325. PMID 9927668.
- 1 2 "Entrez Gene: COG1 component of oligomeric golgi complex 1".
- ↑ Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. (United States) 279 (23): 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703.
- ↑ Loh, Eva; Hong Wanjin (Jun 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. (United States) 277 (24): 21955–61. doi:10.1074/jbc.M202326200. ISSN 0021-9258. PMID 11929878.
Further reading
- Nagase T, Kikuno R, Ishikawa KI; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
- Loh E, Hong W (2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp.". J. Biol. Chem. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. PMID 11929878.
- Ungar D, Oka T, Brittle EE; et al. (2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function.". J. Cell Biol. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Loh E, Hong W (2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex.". J. Biol. Chem. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. PMID 15047703.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ungar D, Oka T, Vasile E; et al. (2005). "Subunit architecture of the conserved oligomeric Golgi complex.". J. Biol. Chem. 280 (38): 32729–35. doi:10.1074/jbc.M504590200. PMID 16020545.
- Vasile E, Oka T, Ericsson M; et al. (2006). "IntraGolgi distribution of the Conserved Oligomeric Golgi (COG) complex.". Exp. Cell Res. 312 (16): 3132–41. doi:10.1016/j.yexcr.2006.06.005. PMID 16857184.
External links
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