COP1

For the membrane coated vesicle used in transport, see here.

Caspase recruitment domain family, member 16
Identifiers
Symbols	CARD16 ; COP; COP1; PSEUDO-ICE
External IDs	OMIM: 615680 HomoloGene: 133086 GeneCards: CARD16 Gene
Gene ontology Molecular function • cysteine-type endopeptidase inhibitor activity Cellular component • intracellular Biological process • negative regulation of endopeptidase activity • regulation of apoptotic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	114769	n/a
Ensembl	ENSG00000204397	n/a
UniProt	Q5EG05	n/a
RefSeq (mRNA)	NM_001017534	n/a
RefSeq (protein)	NP_001017534	n/a
Location (UCSC)	Chr 11: 105.04 – 105.1 Mb	n/a
PubMed search		n/a

Fagol Caspase recruitment domain-containing protein 16 is an enzyme that in humans is encoded by the CARD16 gene.^[1][2][3]

References

1. Lee SH, Stehlik C, Reed JC (Sep 2001). "Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing". J Biol Chem 276 (37): 34495–500. doi:10.1074/jbc.M101415200. PMID 11432859.
2. Druilhe A, Srinivasula SM, Razmara M, Ahmad M, Alnemri ES (Sep 2001). "Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins". Cell Death Differ 8 (6): 649–57. doi:10.1038/sj.cdd.4400881. PMID 11536016.
3. "Entrez Gene: COP1 caspase-1 dominant-negative inhibitor pseudo-ICE".

Further reading

• Wang X, Narayanan M, Bruey JM; et al. (2006). "Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death.". Biochim. Biophys. Acta 1762 (8): 742–54. doi:10.1016/j.bbadis.2006.06.015. PMID 16920334.
• Wang X, Wang H, Figueroa BE; et al. (2006). "Dysregulation of receptor interacting protein-2 and caspase recruitment domain only protein mediates aberrant caspase-1 activation in Huntington's disease.". J. Neurosci. 25 (50): 11645–54. doi:10.1523/JNEUROSCI.4181-05.2005. PMID 16354923.
• Lamkanfi M, Denecker G, Kalai M; et al. (2005). "INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation.". J. Biol. Chem. 279 (50): 51729–38. doi:10.1074/jbc.M407891200. PMID 15383541.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Razmara M, Srinivasula SM, Wang L; et al. (2002). "CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.". J. Biol. Chem. 277 (16): 13952–8. doi:10.1074/jbc.M107811200. PMID 11821383.