COP9 signalosome complex subunit 3

COP9 signalosome subunit 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4D10​, 4D18​
Identifiers
Symbols	COPS3 ; CSN3; SGN3
External IDs	OMIM: 604665 MGI: 1349409 HomoloGene: 2710 GeneCards: COPS3 Gene
Gene ontology Molecular function • protein binding Cellular component • nucleus • nucleoplasm • cytoplasm • COP9 signalosome Biological process • in utero embryonic development • ubiquitin-dependent protein catabolic process • signal transduction • response to light stimulus • cullin deneddylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8533	26572
Ensembl	ENSG00000141030	ENSMUSG00000019373
UniProt	Q9UNS2	O88543
RefSeq (mRNA)	NM_001199125	NM_011991
RefSeq (protein)	NP_001186054	NP_036121
Location (UCSC)	Chr 17: 17.25 – 17.28 Mb	Chr 11: 59.82 – 59.84 Mb
PubMed search

COP9 signalosome complex subunit 3 is a protein that in humans is encoded by the COPS3 gene.^[1][2][3] It encodes a subunit of the COP9 signalosome.

The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I-kappa-B-alpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17.^[3]

See also

• Signalosome

References

1. Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (Apr 1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J 12 (6): 469–78. PMID 9535219.
2. Potocki L, Chen KS, Lupski JR (Jun 1999). "Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the smith-magenis syndrome critical region in 17p11.2". Genomics 57 (1): 180–2. doi:10.1006/geno.1998.5748. PMID 10191102.
3. "Entrez Gene: COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)".

Further reading

• Wolf DA, Zhou C, Wee S (2004). "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol. 5 (12): 1029–33. doi:10.1038/ncb1203-1029. PMID 14647295.
• van Dartel M, Hulsebos TJ (2004). "Amplification and overexpression of genes in 17p11.2 ~ p12 in osteosarcoma.". Cancer Genet. Cytogenet. 153 (1): 77–80. doi:10.1016/j.cancergencyto.2004.03.007. PMID 15325100.
• Wei N, Tsuge T, Serino G; et al. (1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex.". Curr. Biol. 8 (16): 919–22. doi:10.1016/S0960-9822(07)00372-7. PMID 9707402.
• Bianchi E, Denti S, Granata A; et al. (2000). "Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity.". Nature 404 (6778): 617–21. doi:10.1038/35007098. PMID 10766246.
• Tsuge T, Matsui M, Wei N (2001). "The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain.". J. Mol. Biol. 305 (1): 1–9. doi:10.1006/jmbi.2000.4288. PMID 11114242.
• Bech-Otschir D, Kraft R, Huang X; et al. (2001). "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system". EMBO J. 20 (7): 1630–9. doi:10.1093/emboj/20.7.1630. PMC 145508. PMID 11285227.
• Lyapina S, Cope G, Shevchenko A; et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science 292 (5520): 1382–5. doi:10.1126/science.1059780. PMID 11337588.
• Hong X, Xu L, Li X; et al. (2001). "CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced NF-kappaB activation". FEBS Lett. 499 (1–2): 133–6. doi:10.1016/S0014-5793(01)02535-2. PMID 11418127.
• Bi W, Yan J, Stankiewicz P; et al. (2002). "Genes in a Refined Smith-Magenis Syndrome Critical Deletion Interval on Chromosome 17p11.2 and the Syntenic Region of the Mouse". Genome Res. 12 (5): 713–28. doi:10.1101/gr.73702. PMC 186594. PMID 11997338.
• Hoareau Alves K, Bochard V, Réty S, Jalinot P (2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3): 15–21. doi:10.1016/S0014-5793(02)03147-2. PMID 12220626.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Petersen HH, Hilpert J, Militz D; et al. (2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule". J. Cell. Sci. 116 (Pt 3): 453–61. doi:10.1242/jcs.00243. PMID 12508107.
• Serino G, Su H, Peng Z; et al. (2003). "Characterization of the Last Subunit of the Arabidopsis COP9 Signalosome: Implications for the Overall Structure and Origin of the Complex". Plant Cell 15 (3): 719–31. doi:10.1105/tpc.009092. PMC 150025. PMID 12615944.
• Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389.
• Uhle S, Medalia O, Waldron R; et al. (2003). "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome". EMBO J. 22 (6): 1302–12. doi:10.1093/emboj/cdg127. PMC 151059. PMID 12628923.
• Gevaert K, Goethals M, Martens L; et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Groisman R, Polanowska J, Kuraoka I; et al. (2003). "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage". Cell 113 (3): 357–67. doi:10.1016/S0092-8674(03)00316-7. PMID 12732143.
• Henriksen J, Aagesen TH, Maelandsmo GM; et al. (2003). "Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation". Oncogene 22 (34): 5358–61. doi:10.1038/sj.onc.1206671. PMID 12917637.