COPS4

COP9 signalosome subunit 4
PDB rendering based on 1ufm.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4D0P​, 4D10​, 4D18​
Identifiers
Symbols	COPS4 ; CSN4
External IDs	OMIM: 616008 MGI: 1349414 HomoloGene: 8067 GeneCards: COPS4 Gene
Gene ontology Molecular function • protein binding Cellular component • nucleus • nucleoplasm • synaptic vesicle • COP9 signalosome • cell junction • extracellular exosome Biological process • protein deneddylation • cullin deneddylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51138	26891
Ensembl	ENSG00000138663	ENSMUSG00000035297
UniProt	Q9BT78	O88544
RefSeq (mRNA)	NM_001258006	NM_012001
RefSeq (protein)	NP_001244935	NP_036131
Location (UCSC)	Chr 4: 83.03 – 83.08 Mb	Chr 5: 100.52 – 100.55 Mb
PubMed search

COP9 signalosome complex subunit 4 is a protein that in humans is encoded by the COPS4 gene.^[1][2]

This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases.^[2]

References

1. Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, Deng XW (Oct 1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex". Curr Biol 8 (16): 919–924. doi:10.1016/S0960-9822(07)00372-7. PMID 9707402.
2. "Entrez Gene: COPS4 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)".

Further reading

• Schwechheimer C, Deng XW (2001). "COP9 signalosome revisited: a novel mediator of protein degradation". Trends Cell Biol. 11 (10): 420–426. doi:10.1016/S0962-8924(01)02091-8. PMID 11567875.
• Wolf DA, Zhou C, Wee S (2004). "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol. 5 (12): 1029–1033. doi:10.1038/ncb1203-1029. PMID 14647295.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Seeger M, Kraft R, Ferrell K, et al. (1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. PMID 9535219.
• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Naumann M, Bech-Otschir D, Huang X, et al. (2000). "COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK". J. Biol. Chem. 274 (50): 35297–35300. doi:10.1074/jbc.274.50.35297. PMID 10585392.
• Cohen H, Azriel A, Cohen T, et al. (2001). "Interaction between Interferon Consensus Sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome". J. Biol. Chem. 275 (50): 39081–39089. doi:10.1074/jbc.M004900200. PMID 10991940.
• Tsuge T, Matsui M, Wei N (2001). "The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain". J. Mol. Biol. 305 (1): 1–9. doi:10.1006/jmbi.2000.4288. PMID 11114242.
• Bech-Otschir D, Kraft R, Huang X, et al. (2001). "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system". EMBO J. 20 (7): 1630–1639. doi:10.1093/emboj/20.7.1630. PMC 145508. PMID 11285227.
• Lyapina S, Cope G, Shevchenko A, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science 292 (5520): 1382–1385. doi:10.1126/science.1059780. PMID 11337588.
• Peyrl A, Weitzdoerfer R, Gulesserian T, et al. (2003). "Aberrant expression of signaling-related proteins 14-3-3 gamma and RACK1 in fetal Down syndrome brain (trisomy 21)". Electrophoresis 23 (1): 152–7. doi:10.1002/1522-2683(200201)23:1<152::AID-ELPS152>3.0.CO;2-T. PMID 11824616.
• Hoareau Alves K, Bochard V, Réty S, Jalinot P (2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3): 15–21. doi:10.1016/S0014-5793(02)03147-2. PMID 12220626.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Serino G, Su H, Peng Z, et al. (2003). "Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex". Plant Cell 15 (3): 719–731. doi:10.1105/tpc.009092. PMC 150025. PMID 12615944.
• Uhle S, Medalia O, Waldron R, et al. (2003). "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome". EMBO J. 22 (6): 1302–1312. doi:10.1093/emboj/cdg127. PMC 151059. PMID 12628923.
• Groisman R, Polanowska J, Kuraoka I, et al. (2003). "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage". Cell 113 (3): 357–367. doi:10.1016/S0092-8674(03)00316-7. PMID 12732143.