CORO1C

Coronin, actin binding protein, 1C
Identifiers
Symbols	CORO1C ; HCRNN4
External IDs	OMIM: 605269 MGI: 1345964 HomoloGene: 56537 GeneCards: CORO1C Gene
Gene ontology Molecular function • protein binding • Rac GTPase binding • actin filament binding Cellular component • cytoplasm • focal adhesion • actin cytoskeleton • lateral plasma membrane • flotillin complex • lamellipodium • vesicle Biological process • neural crest cell migration • regulation of protein phosphorylation • negative regulation of protein phosphorylation • phagocytosis • signal transduction • regulation of epithelial cell migration • negative regulation of epithelial cell migration • regulation of fibroblast migration • actin cytoskeleton organization • negative regulation of protein kinase activity by regulation of protein phosphorylation • establishment of protein localization • regulation of focal adhesion assembly • negative regulation of focal adhesion assembly • activation of GTPase activity • regulation of substrate adhesion-dependent cell spreading • negative regulation of substrate adhesion-dependent cell spreading • regulation of ruffle assembly • positive regulation of lamellipodium morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23603	23790
Ensembl	ENSG00000110880	ENSMUSG00000004530
UniProt	Q9ULV4	Q9WUM4
RefSeq (mRNA)	NM_001105237	NM_011779
RefSeq (protein)	NP_001098707	NP_035909
Location (UCSC)	Chr 12: 108.65 – 108.73 Mb	Chr 5: 113.84 – 113.91 Mb
PubMed search

Coronin-1C is a protein that in humans is encoded by the CORO1C gene.^[1][2][3]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.^[3]

References

1. Okumura M, Kung C, Wong S, Rodgers M, Thomas ML (Oct 1998). "Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein". DNA Cell Biol 17 (9): 779–87. doi:10.1089/dna.1998.17.779. PMID 9778037.
2. de Hostos EL (Oct 1999). "The coronin family of actin-associated proteins". Trends Cell Biol 9 (9): 345–50. doi:10.1016/S0962-8924(99)01620-7. PMID 10461187.
3. "Entrez Gene: CORO1C coronin, actin binding protein, 1C".

Further reading

• Rosentreter A, Hofmann A, Xavier CP; et al. (2007). "Coronin 3 involvement in F-actin-dependent processes at the cell cortex". Exp. Cell Res. 313 (5): 878–95. doi:10.1016/j.yexcr.2006.12.015. PMID 17274980.
• Rush J, Moritz A, Lee KA; et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Spoerl Z, Stumpf M, Noegel AA, Hasse A (2003). "Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus". J. Biol. Chem. 277 (50): 48858–67. doi:10.1074/jbc.M205136200. PMID 12377779.
• Iizaka M, Han HJ, Akashi H; et al. (2000). "Isolation and chromosomal assignment of a novel human gene, CORO1C, homologous to coronin-like actin-binding proteins". Cytogenet. Cell Genet. 88 (3–4): 221–4. doi:10.1159/000015555. PMID 10828594.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wick M, Bürger C, Brüsselbach S; et al. (1994). "Identification of serum-inducible genes: different patterns of gene regulation during G0-->S and G1-->S progression". J. Cell. Sci. 107 (1): 227–39. PMID 8175911.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.