CORO2A
| Coronin, actin binding protein, 2A | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | CORO2A ; CLIPINB; IR10; WDR2 | ||||||||||||
| External IDs | OMIM: 602159 HomoloGene: 2546 GeneCards: CORO2A Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 7464 | 107684 | |||||||||||
| Ensembl | ENSG00000106789 | ENSMUSG00000028337 | |||||||||||
| UniProt | Q92828 | Q8C0P5 | |||||||||||
| RefSeq (mRNA) | NM_003389 | NM_001164804 | |||||||||||
| RefSeq (protein) | NP_003380 | NP_001158276 | |||||||||||
| Location (UCSC) |
Chr 9: 98.12 – 98.19 Mb |
Chr 4: 46.54 – 46.6 Mb | |||||||||||
| PubMed search | |||||||||||||
Coronin, actin binding protein, 2A is a protein that in humans is encoded by the CORO2A gene.[1]
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008].[1]
References
- 1 2 "Entrez Gene: Coronin, actin binding protein, 2A". Retrieved 2012-01-03.
Further reading
- Yoon, H. -G.; Chan, D. W.; Huang, Z. Q.; Li, J.; Fondell, J. D.; Qin, J.; Wong, J. (2003). "Purification and functional characterization of the human N-CoR complex: The roles of HDAC3, TBL1 and TBLR1". The EMBO Journal 22 (6): 1336–1346. doi:10.1093/emboj/cdg120. PMC 151047. PMID 12628926.
- Yoon, H. G.; Chan, D. W.; Reynolds, A. B.; Qin, J.; Wong, J. (2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Molecular Cell 12 (3): 723–734. doi:10.1016/j.molcel.2003.08.008. PMID 14527417.
- Marshall, T. W.; Aloor, H. L.; Bear, J. E. (2009). "Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway". Journal of Cell Science 122 (17): 3061–3069. doi:10.1242/jcs.051482. PMC 2729258. PMID 19654210.
- Jin, Y.; Birlea, S. A.; Fain, P. R.; Mailloux, C. M.; Riccardi, S. L.; Gowan, K.; Holland, P. J.; Bennett, D. C.; Wallace, M. R.; McCormack, W. T.; Kemp, E. H.; Gawkrodger, D. J.; Weetman, A. P.; Picardo, M.; Leone, G.; Taïeb, A.; Jouary, T.; Ezzedine, K.; Van Geel, N.; Lambert, J.; Overbeck, A.; Spritz, R. A. (2010). "Common variants in FOXP1 are associated with generalized vitiligo". Nature Genetics 42 (7): 576–578. doi:10.1038/ng.602. PMC 2893242. PMID 20526340.
- Zaphiropoulos, P. G.; Toftgård, R. (1996). "CDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region". DNA and cell biology 15 (12): 1049–1056. PMID 8985118.