COTL1

Coactosin-like F-actin binding protein 1

PDB rendering based on 1t2l.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols COTL1 ; CLP
External IDs OMIM: 606748 MGI: 1919292 HomoloGene: 10898 GeneCards: COTL1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 23406 72042
Ensembl ENSG00000103187 ENSMUSG00000031827
UniProt Q14019 Q9CQI6
RefSeq (mRNA) NM_021149 NM_028071
RefSeq (protein) NP_066972 NP_082347
Location (UCSC) Chr 16:
84.57 – 84.62 Mb
Chr 8:
119.81 – 119.84 Mb
PubMed search

Coactosin-like protein is a protein that in humans is encoded by the COTL1 gene.[1][2][3][4]

Function

This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.[4]

Interactions

COTL1 has been shown to interact with Arachidonate 5-lipoxygenase.[5]

References

  1. Provost P, Samuelsson B, Rådmark O (Apr 1999). "Interaction of 5-lipoxygenase with cellular proteins". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1881–5. doi:10.1073/pnas.96.5.1881. PMC 26705. PMID 10051563.
  2. Chen KS, Manian P, Koeuth T, Potocki L, Zhao Q, Chinault AC, Lee CC, Lupski JR (Nov 1997). "Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous gene deletion syndrome". Nat. Genet. 17 (2): 154–63. doi:10.1038/ng1097-154. PMID 9326934.
  3. Rakonjac M, Fischer L, Provost P, Werz O, Steinhilber D, Samuelsson B, Rådmark O (Sep 2006). "Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production". Proc. Natl. Acad. Sci. U.S.A. 103 (35): 13150–5. doi:10.1073/pnas.0605150103. PMC 1559768. PMID 16924104.
  4. 1 2 "Entrez Gene: COTL1 coactosin-like 1 (Dictyostelium)".
  5. Provost P, Doucet J, Hammarberg T, Gerisch G, Samuelsson B, Radmark O (May 2001). "5-Lipoxygenase interacts with coactosin-like protein". J. Biol. Chem. 276 (19): 16520–7. doi:10.1074/jbc.M011205200. PMID 11297527.

Further reading


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