COX6B2
| Cytochrome c oxidase subunit VIb polypeptide 2 (testis) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | COX6B2 ; COXVIB2; CT59 | ||||||||||||
| External IDs | HomoloGene: 16948 GeneCards: COX6B2 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 125965 | 333182 | |||||||||||
| Ensembl | ENSG00000160471 | ENSMUSG00000051811 | |||||||||||
| UniProt | Q6YFQ2 | Q80ZN9 | |||||||||||
| RefSeq (mRNA) | NM_144613 | NM_001289848 | |||||||||||
| RefSeq (protein) | NP_653214 | NP_001276777 | |||||||||||
| Location (UCSC) |
Chr 19: 55.35 – 55.35 Mb |
Chr 7: 4.75 – 4.75 Mb | |||||||||||
| PubMed search | |||||||||||||
Cytochrome c oxidase subunit VIb polypeptide 2 is a protein that in humans is encoded by the COX6B2 gene. Cytochrome c oxidase 6B2 is a subunit of the cytochrome c oxidase complex, also known as Complex IV, the last enzyme in the mitochondrial electron transport chain.[1]
Structure
The COX6B2 gene, located on the q arm of chromosome 19 in position 13.42, contains 5 exons and is 5,113 base pairs in length.[1] The protein encoded by the COX6B2 gene weighs 11 kDa and is composed of 88 amino acids.[2][3] The protein is a subunit of Complex IV, a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes.[1]
Function
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane to drive ATP synthesis via protonmotive force. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex.[1]
Summary reaction:
- 4 Fe2+-cytochrome c + 8 H+in + O2 → 4 Fe3+-cytochrome c + 2 H2O + 4 H+out[4]
References
- 1 2 3 4 "Entrez Gene: Cytochrome c oxidase subunit VIb polypeptide 2".
- ↑ Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (Oct 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.
- ↑ "Cytochrome c oxidase subunit VIb polypeptide 2". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB).
- ↑ Voet D, Voet JG, Pratt CW (2013). "Chapter 18". Fundamentals of biochemistry: life at the molecular level (4th ed.). Hoboken, NJ: Wiley. pp. 581–620. ISBN 978-0-470-54784-7.
Further reading
- Taanman JW, Schrage C, Ponne NJ, Das AT, Bolhuis PA, de Vries H, Agsteribbe E (Sep 1990). "Isolation of cDNAs encoding subunit VIb of cytochrome c oxidase and steady-state levels of coxVIb mRNA in different tissues". Gene 93 (2): 285–91. doi:10.1016/0378-1119(90)90237-l. PMID 2172092.
- Hüttemann M, Jaradat S, Grossman LI (Sep 2003). "Cytochrome c oxidase of mammals contains a testes-specific isoform of subunit VIb--the counterpart to testes-specific cytochrome c?". Molecular Reproduction and Development 66 (1): 8–16. doi:10.1002/mrd.10327. PMID 12874793.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.