COX6C

Cytochrome c oxidase subunit VIc
Identifiers
Symbol	COX6C
External IDs	OMIM: 124090 MGI: 104614 HomoloGene: 3220 GeneCards: COX6C Gene
EC number	1.9.3.1
Gene ontology Molecular function • cytochrome-c oxidase activity Cellular component • mitochondrion • mitochondrial inner membrane • integral component of membrane Biological process • generation of precursor metabolites and energy • transcription initiation from RNA polymerase II promoter • gene expression • respiratory electron transport chain • cellular metabolic process • small molecule metabolic process • hydrogen ion transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1345	12864
Ensembl	ENSG00000164919	ENSMUSG00000014313
UniProt	P09669	Q9CPQ1
RefSeq (mRNA)	NM_004374	NM_053071
RefSeq (protein)	NP_004365	NP_444301
Location (UCSC)	Chr 8: 99.87 – 99.89 Mb	Chr 15: 35.93 – 35.94 Mb
PubMed search

Cytochrome c oxidase subunit 6C is an enzyme that in humans is encoded by the COX6C gene.^[1][2]

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse COX subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene COX6CP1 has been found on chromosomes 16p12.^[2]

References

1. Hofmann S, Lichtner P, Schuffenhauer S, Gerbitz KD, Meitinger T (Mar 1999). "Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22→q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14→q21 by FISH and radiation hybrid mapping". Cytogenet Cell Genet 83 (3-4): 226–7. doi:10.1159/000015185. PMID 10072584.
2. "Entrez Gene: COX6C cytochrome c oxidase subunit VIc".

Further reading

• Lenka N, Vijayasarathy C, Mullick J, Avadhani NG (1998). "Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex.". Prog. Nucleic Acid Res. Mol. Biol. 61: 309–44. doi:10.1016/S0079-6603(08)60830-2. PMID 9752724.
• Sirchia R, Luparello C (2007). "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells.". Biol. Chem. 388 (5): 457–65. doi:10.1515/BC.2007.059. PMID 17516841.
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kish SJ, Mastrogiacomo F, Guttman M; et al. (1999). "Decreased brain protein levels of cytochrome oxidase subunits in Alzheimer's disease and in hereditary spinocerebellar ataxia disorders: a nonspecific change?". J. Neurochem. 72 (2): 700–7. doi:10.1046/j.1471-4159.1999.0720700.x. PMID 9930743.
• Wang FL, Wang Y, Wong WK; et al. (1996). "Two differentially expressed genes in normal human prostate tissue and in carcinoma.". Cancer Res. 56 (16): 3634–7. PMID 8705997.
• Otsuka M, Mizuno Y, Yoshida M; et al. (1989). "Nucleotide sequence of cDNA encoding human cytochrome c oxidase subunit VIc.". Nucleic Acids Res. 16 (22): 10916. doi:10.1093/nar/16.22.10916. PMC 338951. PMID 2849755.