COX7A2

Cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
Identifiers
Symbols COX7A2 ; COX7AL; COX7AL1; COXVIIAL; COXVIIa-L; VIIAL
External IDs OMIM: 123996 MGI: 1316715 HomoloGene: 36082 GeneCards: COX7A2 Gene
EC number 1.9.3.1
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 1347 12866
Ensembl ENSG00000112695 ENSMUSG00000032330
UniProt P14406 P48771
RefSeq (mRNA) NM_001865 NM_009945
RefSeq (protein) NP_001856 NP_034075
Location (UCSC) Chr 6:
75.24 – 75.25 Mb
Chr 9:
79.76 – 79.76 Mb
PubMed search

Cytochrome c oxidase polypeptide 7A2, mitochondrial is an enzyme that in humans is encoded by the COX7A2 gene.[1][2][3]

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa and the polypeptide 2 is present in both muscle and nonmuscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, present in all tissues. This gene may have several pseudogenes.[3]

References

  1. Arnaudo E, Hirano M, Seelan RS, Milatovich A, Hsieh CL, Fabrizi GM, Grossman LI, Francke U, Schon EA (Nov 1992). "Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase". Gene 119 (2): 299–305. doi:10.1016/0378-1119(92)90287-Y. PMID 1327965.
  2. Merante F, Duncan AM, Mitchell G, Duff C, Rommens J, Robinson BH (Aug 1997). "Chromosomal localization of the human liver form cytochrome c oxidase subunit VIIa gene". Genome 40 (3): 318–24. doi:10.1139/g97-044. PMID 9202412.
  3. 1 2 "Entrez Gene: COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver)".

Further reading


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