COX7C

Cytochrome c oxidase subunit VIIc
Identifiers
Symbol	COX7C
External IDs	OMIM: 603774 MGI: 103226 HomoloGene: 135674 GeneCards: COX7C Gene
EC number	1.9.3.1
Gene ontology Molecular function • cytochrome-c oxidase activity Cellular component • mitochondrion • mitochondrial inner membrane • integral component of membrane Biological process • generation of precursor metabolites and energy • transcription initiation from RNA polymerase II promoter • gene expression • respiratory electron transport chain • cellular metabolic process • small molecule metabolic process • hydrogen ion transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1350	12867
Ensembl	ENSG00000127184	ENSMUSG00000017778
UniProt	P15954	P17665
RefSeq (mRNA)	NM_001867	NM_007749
RefSeq (protein)	NP_001858	NP_031775
Location (UCSC)	Chr 5: 86.62 – 86.62 Mb	Chr 13: 86.04 – 86.05 Mb
PubMed search

Cytochrome c oxidase subunit 7C, mitochondrial is an enzyme that in humans is encoded by the COX7C gene.^[1][2]

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13.^[2]

References

1. Hofmann S, Lichtner P, Schuffenhauer S, Gerbitz KD, Meitinger T (Mar 1999). "Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22→q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14→q21 by FISH and radiation hybrid mapping". Cytogenet Cell Genet 83 (3-4): 226–7. doi:10.1159/000015185. PMID 10072584.
2. "Entrez Gene: COX7C cytochrome c oxidase subunit VIIc".

Further reading

• Lenka N, Vijayasarathy C, Mullick J, Avadhani NG (1998). "Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex.". Prog. Nucleic Acid Res. Mol. Biol. 61: 309–44. doi:10.1016/S0079-6603(08)60830-2. PMID 9752724.
• Sirchia R, Luparello C (2007). "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells.". Biol. Chem. 388 (5): 457–65. doi:10.1515/BC.2007.059. PMID 17516841.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kaminishi H, Hamatake H, Cho T; et al. (1994). "Activation of blood clotting factors by microbial proteinases.". FEMS Microbiol. Lett. 121 (3): 327–32. doi:10.1111/j.1574-6968.1994.tb07121.x. PMID 7926688.
• Koga Y, Fabrizi GM, Mita S; et al. (1990). "Sequence of a cDNA specifying subunit VIIc of human cytochrome c oxidase.". Nucleic Acids Res. 18 (3): 684. doi:10.1093/nar/18.3.684. PMC 333506. PMID 2155413.
• Van Kuilenburg AB, Van Beeumen JJ, Van der Meer NM, Muijsers AO (1992). "Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart.". Eur. J. Biochem. 203 (1-2): 193–9. doi:10.1111/j.1432-1033.1992.tb19847.x. PMID 1309697.