CPNE1

Copine I
Identifiers
Symbols	CPNE1 ; COPN1; CPN1
External IDs	OMIM: 604205 MGI: 2386621 HomoloGene: 36501 GeneCards: CPNE1 Gene
Gene ontology Molecular function • phosphatidylserine binding • endopeptidase activity • transporter activity • calcium ion binding • calcium-dependent phospholipid binding • protein homodimerization activity • NF-kappaB binding Cellular component • nucleus • cytoplasm • cytosol • plasma membrane • membrane • extracellular exosome Biological process • proteolysis • lipid metabolic process • phospholipid metabolic process • negative regulation of gene expression • vesicle-mediated transport • regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of DNA binding • small molecule metabolic process • positive regulation of neuron differentiation • glycerophospholipid biosynthetic process • positive regulation of protein kinase B signaling • cellular response to calcium ion • negative regulation of NIK/NF-kappaB signaling • positive regulation of tumor necrosis factor-mediated signaling pathway • neuron projection extension Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8904	266692
Ensembl	ENSG00000214078	ENSMUSG00000074643
UniProt	Q99829	Q8C166
RefSeq (mRNA)	NM_001198863	NM_170588
RefSeq (protein)	NP_001185792	NP_733467
Location (UCSC)	Chr 20: 35.63 – 35.66 Mb	Chr 2: 156.07 – 156.11 Mb
PubMed search

Copine-1 is a protein that in humans is encoded by the CPNE1 gene.^[1][2]

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Sequence analysis identified multiple alternatively spliced variants in the 5' UTR. All variants encode the same protein.^[2]

References

1. Creutz CE, Tomsig JL, Snyder SL, Gautier MC, Skouri F, Beisson J, Cohen J (Feb 1998). "The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans". J Biol Chem 273 (3): 1393–402. doi:10.1074/jbc.273.3.1393. PMID 9430674.
2. "Entrez Gene: CPNE1 copine I".

Further reading

• Savino M, d'Apolito M, Centra M; et al. (1999). "Characterization of copine VII, a new member of the copine family, and its exclusion as a candidate in sporadic breast cancers with loss of heterozygosity at 16q24.3.". Genomics 61 (2): 219–26. doi:10.1006/geno.1999.5958. PMID 10534407.
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tomsig JL, Snyder SL, Creutz CE (2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.". J. Biol. Chem. 278 (12): 10048–54. doi:10.1074/jbc.M212632200. PMID 12522145.
• Cowland JB, Carter D, Bjerregaard MD; et al. (2003). "Tissue expression of copines and isolation of copines I and III from the cytosol of human neutrophils.". J. Leukoc. Biol. 74 (3): 379–88. doi:10.1189/jlb.0203083. PMID 12949241.
• Tomsig JL, Sohma H, Creutz CE (2004). "Calcium-dependent regulation of tumour necrosis factor-alpha receptor signalling by copine.". Biochem. J. 378 (Pt 3): 1089–94. doi:10.1042/BJ20031654. PMC 1224034. PMID 14674885.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Ma J, Dempsey AA, Stamatiou D; et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.". Atherosclerosis 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.