CPNE4
| Copine 4 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | CPNE4 ; COPN4; CPN4 | ||||||||||
| External IDs | OMIM: 604208 MGI: 1921270 HomoloGene: 26078 GeneCards: CPNE4 Gene | ||||||||||
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| RNA expression pattern | |||||||||||
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| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 131034 | 74020 | |||||||||
| Ensembl | ENSG00000196353 | ENSMUSG00000032564 | |||||||||
| UniProt | Q96A23 | Q8BLR2 | |||||||||
| RefSeq (mRNA) | NM_001289112 | NM_028719 | |||||||||
| RefSeq (protein) | NP_001276041 | NP_082995 | |||||||||
| Location (UCSC) |
Chr 3: 131.53 – 132.29 Mb |
Chr 9: 104.55 – 105.03 Mb | |||||||||
| PubMed search | |||||||||||
Copine-4 is a protein that in humans is encoded by the CPNE4 gene.[1][2][3]
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus.[3]
References
- ↑ Creutz CE, Tomsig JL, Snyder SL, Gautier MC, Skouri F, Beisson J, Cohen J (Feb 1998). "The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans". J Biol Chem 273 (3): 1393–402. doi:10.1074/jbc.273.3.1393. PMID 9430674.
- ↑ Maitra R, Grigoryev DN, Bera TK, Pastan IH, Lee B (Apr 2003). "Cloning, molecular characterization, and expression analysis of Copine 8". Biochem Biophys Res Commun 303 (3): 842–7. doi:10.1016/S0006-291X(03)00445-5. PMID 12670487.
- 1 2 "Entrez Gene: CPNE4 copine IV".
Further reading
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Tomsig JL, Snyder SL, Creutz CE (2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.". J. Biol. Chem. 278 (12): 10048–54. doi:10.1074/jbc.M212632200. PMID 12522145.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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