CPNE6

Copine VI (neuronal)
Identifiers
Symbols	CPNE6 ; N-COPINE
External IDs	OMIM: 605688 MGI: 1334445 HomoloGene: 81815 GeneCards: CPNE6 Gene
Gene ontology Molecular function • phosphatidylserine binding • transporter activity • calcium ion binding • protein binding Cellular component • plasma membrane • axon • dendrite • extracellular exosome Biological process • lipid metabolic process • phospholipid metabolic process • synaptic transmission • nervous system development • vesicle-mediated transport • small molecule metabolic process • glycerophospholipid biosynthetic process • positive regulation of dendrite extension Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9362	12891
Ensembl	ENSG00000100884	ENSMUSG00000022212
UniProt	O95741	Q9Z140
RefSeq (mRNA)	NM_001280558	NM_001136057
RefSeq (protein)	NP_001267487	NP_001129529
Location (UCSC)	Chr 14: 24.07 – 24.08 Mb	Chr 14: 55.51 – 55.52 Mb
PubMed search

Copine-6 is a protein that in humans is encoded by the CPNE6 gene.^[1][2]

This gene encodes a brain-specific member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains, and one von Willebrand factor A domain. It may have a role in synaptic plasticity.^[2]

References

1. Nakayama T, Yaoi T, Yasui M, Kuwajima G (Jul 1998). "N-copine: a novel two C2-domain-containing protein with neuronal activity-regulated expression". FEBS Lett 428 (1–2): 80–4. doi:10.1016/S0014-5793(98)00497-9. PMID 9645480.
2. "Entrez Gene: CPNE6 copine VI (neuronal)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Nakayama T, Yaoi T, Kuwajima G (1999). "Localization and subcellular distribution of N-copine in mouse brain". J. Neurochem. 72 (1): 373–9. doi:10.1046/j.1471-4159.1999.0720373.x. PMID 9886090.
• Nakayama T, Yaoi T, Kuwajima G; et al. (1999). "Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma". FEBS Lett. 453 (1–2): 77–80. doi:10.1016/S0014-5793(99)00700-0. PMID 10403379.
• Caudell EG, Caudell JJ, Tang CH; et al. (2000). "Characterization of human copine III as a phosphoprotein with associated kinase activity". Biochemistry 39 (42): 13034–43. doi:10.1021/bi001250v. PMID 11041869.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.