CRB3

Crumbs family member 3
Identifiers
Symbol	CRB3
External IDs	OMIM: 609737 MGI: 2670904 HomoloGene: 138188 GeneCards: CRB3 Gene
Gene ontology Molecular function • protein binding • SH3 domain binding • protein domain specific binding Cellular component • plasma membrane • bicellular tight junction • integral component of membrane • apical plasma membrane • cell junction • extracellular exosome Biological process • cell junction assembly • cell-cell junction organization • bicellular tight junction assembly • protein localization to plasma membrane Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	92359	224912
Ensembl	ENSG00000130545	ENSMUSG00000044279
UniProt	Q9BUF7	Q8QZT4
RefSeq (mRNA)	NM_139161	NM_177638
RefSeq (protein)	NP_631900	NP_808306
Location (UCSC)	Chr 19: 6.46 – 6.47 Mb	Chr 17: 57.06 – 57.07 Mb
PubMed search

Crumbs protein homolog 3 is a protein that in humans is encoded by the CRB3 gene.^[1]

Function

This gene encodes a member of the Crumbs family of proteins. This protein may play a role in epithelial cell polarity and is associated with tight junctions at the apical surface of epithelial cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[1]

References

1. "Entrez Gene: CRB3 crumbs homolog 3 (Drosophila)".

Further reading

• Lemmers C, Médina E, Delgrossi MH, Michel D, Arsanto JP, Le Bivic A (Jul 2002). "hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells". The Journal of Biological Chemistry 277 (28): 25408–15. doi:10.1074/jbc.M202196200. PMID 11964389.
• Makarova O, Roh MH, Liu CJ, Laurinec S, Margolis B (Jan 2003). "Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1)". Gene 302 (1-2): 21–9. doi:10.1016/S0378111902010843. PMID 12527193.
• Roh MH, Fan S, Liu CJ, Margolis B (Jul 2003). "The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells". Journal of Cell Science 116 (Pt 14): 2895–906. doi:10.1242/jcs.00500. PMID 12771187.
• Lemmers C, Michel D, Lane-Guermonprez L, Delgrossi MH, Médina E, Arsanto JP, Le Bivic A (Mar 2004). "CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells". Molecular Biology of the Cell 15 (3): 1324–33. doi:10.1091/mbc.E03-04-0235. PMC 363137. PMID 14718572.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Fogg VC, Liu CJ, Margolis B (Jul 2005). "Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells". Journal of Cell Science 118 (Pt 13): 2859–69. doi:10.1242/jcs.02412. PMID 15976445.
• Fan S, Fogg V, Wang Q, Chen XW, Liu CJ, Margolis B (Jul 2007). "A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions". The Journal of Cell Biology 178 (3): 387–98. doi:10.1083/jcb.200609096. PMC 2064851. PMID 17646395.