CREB5

CAMP responsive element binding protein 5
Identifiers
Symbols	CREB5 ; CRE-BPA; CREB-5
External IDs	HomoloGene: 18215 GeneCards: CREB5 Gene
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • protein binding • sequence-specific DNA binding • metal ion binding Cellular component • nucleus • extracellular exosome Biological process • transcription from RNA polymerase II promoter • positive regulation of transcription, DNA-templated Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9586	231991
Ensembl	ENSG00000146592	ENSMUSG00000053007
UniProt	Q02930	Q8K1L0
RefSeq (mRNA)	NM_001011666	NM_172728
RefSeq (protein)	NP_001011666	NP_766316
Location (UCSC)	Chr 7: 28.3 – 28.83 Mb	Chr 6: 53.57 – 53.7 Mb
PubMed search

Cyclic AMP-responsive element-binding protein 5 is a protein that in humans is encoded by the CREB5 gene.^[1][2][3]

The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified.^[3]

References

1. Zu YL, Maekawa T, Nomura N, Nakata T, Ishii S (Oct 1993). "Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter TPA". Oncogene 8 (10): 2749–58. PMID 8378084.
2. Nomura N, Zu YL, Maekawa T, Tabata S, Akiyama T, Ishii S (Mar 1993). "Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1". J Biol Chem 268 (6): 4259–66. PMID 8440710.
3. "Entrez Gene: CREB5 cAMP responsive element binding protein 5".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
• <Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.