CRHBP

Corticotropin releasing hormone binding protein
Identifiers
Symbols	CRHBP ; CRF-BP; CRFBP
External IDs	OMIM: 122559 MGI: 88497 HomoloGene: 1418 ChEMBL: 5930 GeneCards: CRHBP Gene
Gene ontology Molecular function • protein binding • peptide binding • corticotropin-releasing hormone binding Cellular component • extracellular space • intracellular • nucleus • secondary lysosome • multivesicular body • endoplasmic reticulum • Golgi apparatus • microtubule • secretory granule • dendrite • dense core granule • varicosity • perikaryon • axon terminus Biological process • synaptic transmission, dopaminergic • maternal aggressive behavior • inflammatory response • signal transduction • female pregnancy • learning or memory • hormone-mediated signaling pathway • cellular response to stress • cellular response to drug • cellular response to potassium ion • hormone metabolic process • regulated secretory pathway • behavioral response to ethanol • regulation of corticotropin secretion • negative regulation of corticotropin secretion • cellular response to calcium ion • cellular response to cocaine • cellular response to cAMP • cellular response to tumor necrosis factor • cellular response to estrogen stimulus • cellular response to estradiol stimulus • cellular response to gonadotropin-releasing hormone • negative regulation of corticotropin-releasing hormone receptor activity • regulation of N-methyl-D-aspartate selective glutamate receptor activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1393	12919
Ensembl	ENSG00000145708	ENSMUSG00000021680
UniProt	P24387	Q60571
RefSeq (mRNA)	NM_001882	NM_198408
RefSeq (protein)	NP_001873	NP_940800
Location (UCSC)	Chr 5: 76.95 – 76.98 Mb	Chr 13: 95.43 – 95.44 Mb
PubMed search

Corticotropin-releasing factor-binding protein is a protein that in humans is encoded by the CRHBP gene.^[1][2] It belongs to corticotropin-releasing hormone binding protein family.

Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy.^[2]

References

1. Behan DP, Potter E, Lewis KA, Jenkins NA, Copeland N, Lowry PJ, Vale WW (Jun 1993). "Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP)". Genomics 16 (1): 63–8. doi:10.1006/geno.1993.1141. PMID 8198617.
2. "Entrez Gene: CRHBP corticotropin releasing hormone binding protein".

Further reading

• Behan DP, De Souza EB, Lowry PJ; et al. (1996). "Corticotropin releasing factor (CRF) binding protein: a novel regulator of CRF and related peptides.". Frontiers in neuroendocrinology 16 (4): 362–82. doi:10.1006/frne.1995.1013. PMID 8557170.
• Westphal NJ, Seasholtz AF (2006). "CRH-BP: the regulation and function of a phylogenetically conserved binding protein.". Front. Biosci. 11: 1878–91. doi:10.2741/1931. PMID 16368564.
• Potter E, Behan DP, Fischer WH; et al. (1991). "Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins.". Nature 349 (6308): 423–6. doi:10.1038/349423a0. PMID 1846945.
• Behan DP, Linton EA, Lowry PJ (1989). "Isolation of the human plasma corticotrophin-releasing factor-binding protein.". J. Endocrinol. 122 (1): 23–31. doi:10.1677/joe.0.1220023. PMID 2549150.
• Behan DP, Heinrichs SC, Troncoso JC; et al. (1995). "Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease.". Nature 378 (6554): 284–7. doi:10.1038/378284a0. PMID 7477348.
• Vamvakopoulos NC, Sioutopoulou TO, Durkin SA; et al. (1995). "Mapping the human corticotropin releasing hormone binding protein gene (CRHBP) to the long arm of chromosome 5 (5q11.2-q13.3).". Genomics 25 (1): 325–7. doi:10.1016/0888-7543(95)80151-B. PMID 7774945.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Fischer WH, Behan DP, Park M; et al. (1994). "Assignment of disulfide bonds in corticotropin-releasing factor-binding protein". J. Biol. Chem. 269 (6): 4313–6. PMID 8307998.
• Donaldson CJ, Sutton SW, Perrin MH; et al. (1996). "Cloning and characterization of human urocortin". Endocrinology 137 (5): 2167–70. doi:10.1210/en.137.5.2167. PMID 8612563.
• Asakura H, Zwain IH, Yen SS (1997). "Expression of genes encoding corticotropin-releasing factor (CRF), type 1 CRF receptor, and CRF-binding protein and localization of the gene products in the human ovary". J. Clin. Endocrinol. Metab. 82 (8): 2720–5. doi:10.1210/jc.82.8.2720. PMID 9253360.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wetzka B, Sehringer B, Schäfer WR; et al. (2004). "Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at term". Exp. Clin. Endocrinol. Diabetes 111 (3): 154–61. doi:10.1055/s-2003-39778. PMID 12784189.
• Claes S, Villafuerte S, Forsgren T; et al. (2003). "The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden". Biol. Psychiatry 54 (9): 867–72. doi:10.1016/S0006-3223(03)00425-6. PMID 14573312.
• Sehringer B, Zahradnik HP, Simon M; et al. (2005). "mRNA expression profiles for corticotrophin-releasing hormone, urocortin, CRH-binding protein and CRH receptors in human term gestational tissues determined by real-time quantitative RT-PCR". J. Mol. Endocrinol. 32 (2): 339–48. doi:10.1677/jme.0.0320339. PMID 15072543.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Herringa RJ, Roseboom PH, Kalin NH (2006). "Decreased amygdala CRF-binding protein mRNA in post-mortem tissue from male but not female bipolar and schizophrenic subjects". Neuropsychopharmacology 31 (8): 1822–31. doi:10.1038/sj.npp.1301038. PMID 16482088.