CRIM1

Cysteine rich transmembrane BMP regulator 1 (chordin-like)
Identifiers
Symbols	CRIM1 ; CRIM-1; S52
External IDs	OMIM: 606189 MGI: 1354756 HomoloGene: 9510 GeneCards: CRIM1 Gene
Gene ontology Molecular function • serine-type endopeptidase inhibitor activity • insulin-like growth factor-activated receptor activity • insulin-like growth factor binding • PDZ domain binding Cellular component • plasma membrane • integral component of membrane • extracellular exosome Biological process • regulation of cell growth • nervous system development • negative regulation of endopeptidase activity • insulin-like growth factor receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51232	50766
Ensembl	ENSG00000150938	ENSMUSG00000024074
UniProt	Q9NZV1	Q9JLL0
RefSeq (mRNA)	NM_016441	NM_015800
RefSeq (protein)	NP_057525	NP_056615
Location (UCSC)	Chr 2: 36.36 – 36.55 Mb	Chr 17: 78.2 – 78.38 Mb
PubMed search

Cysteine-rich motor neuron 1 protein is a protein that in humans is encoded by the CRIM1 gene.^[1][2]

Function

Motor neurons are among the earliest neurons to appear after the commencement of cell patterning and the beginning of cell differentiation. Differentiation occurs in a ventral-to-dorsal gradient and is mediated, at least in part, by the concentration of ventrally expressed sonic hedgehog protein (SHH; MIM 600725). Dorsally expressed factors, such as members of the bone morphogenic protein (e.g., BMP4; MIM 112262) and transforming growth factor-beta (e.g., TGFB1; MIM 190180) families, can repress the induction of these neurons. CRIM1 may interact with growth factors implicated in motor neuron differentiation and survival.^[1][2]

Clinical significance

Loss of Crim1 function as demonstrated by the Crim1 KST264 hypomorph mice resulted in onset of chronic kidney disease with accompanying pathology including papillary hypoplasia, functional urinary tract obstruction, ectopic collagen accumulation within the endothelium and tubulointerstitial fibrosis which was in part attributed by (endothelial) epithelial–mesenchymal transition.^[3][4]

References

1. Kolle G, Georgas K, Holmes GP, Little MH, Yamada T (Feb 2000). "CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis". Mechanisms of Development 90 (2): 181–93. doi:10.1016/S0925-4773(99)00248-8. PMID 10642437.
2. "Entrez Gene: CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)".
3. Phua YL, Martel N, Pennisi DJ, Little MH, Wilkinson L (Apr 2013). "Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins". The Journal of Pathology 229 (5): 685–96. doi:10.1002/path.4155. PMID 23224993.
4. Wilkinson L, Kurniawan ND, Phua YL, Nguyen MJ, Li J, Galloway GJ, Hashitani H, Lang RJ, Little MH (Aug 2012). "Association between congenital defects in papillary outgrowth and functional obstruction in Crim1 mutant mice". The Journal of Pathology 227 (4): 499–510. doi:10.1002/path.4036. PMID 22488641.

Further reading

• Wilkinson L, Kurniawan ND, Phua YL, Nguyen MJ, Li J, Galloway GJ, Hashitani H, Lang RJ, Little MH (Aug 2012). "Association between congenital defects in papillary outgrowth and functional obstruction in Crim1 mutant mice". The Journal of Pathology 227 (4): 499–510. doi:10.1002/path.4036. PMID 22488641.
• Phua YL, Martel N, Pennisi DJ, Little MH, Wilkinson L (Apr 2013). "Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins". The Journal of Pathology 229 (5): 685–96. doi:10.1002/path.4155. PMID 23224993.
• Pennisi DJ, Wilkinson L, Kolle G, Sohaskey ML, Gillinder K, Piper MJ, McAvoy JW, Lovicu FJ, Little MH (Feb 2007). "Crim1KST264/KST264 mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems". Developmental Dynamics 236 (2): 502–11. doi:10.1002/dvdy.21015. PMID 17106887.
• Zhang Z, Henzel WJ (Oct 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Wilkinson L, Kolle G, Wen D, Piper M, Scott J, Little M (Sep 2003). "CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface". The Journal of Biological Chemistry 278 (36): 34181–8. doi:10.1074/jbc.M301247200. PMID 12805376.
• Glienke J, Sturz A, Menrad A, Thierauch KH (Dec 2002). "CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo". Mechanisms of Development 119 (2): 165–75. doi:10.1016/S0925-4773(02)00355-6. PMID 12464430.
• Georgas K, Bowles J, Yamada T, Koopman P, Little MH (Dec 2000). "Characterisation of Crim1 expression in the developing mouse urogenital tract reveals a sexually dimorphic gonadal expression pattern". Developmental Dynamics 219 (4): 582–7. doi:10.1002/1097-0177(2000)9999:9999<::AID-DVDY1072>3.0.CO;2-I. PMID 11084657.