CRIPT

Cysteine-rich PDZ-binding protein
Identifiers
Symbols	CRIPT ; HSPC139; SSMDF
External IDs	OMIM: 604594 MGI: 1929655 HomoloGene: 8572 GeneCards: CRIPT Gene
Gene ontology Molecular function • protein binding • microtubule binding • PDZ domain binding • protein complex binding • scaffold protein binding Cellular component • nucleus • nucleolus • cytoplasm • postsynaptic density • cell junction • dendrite • neuronal cell body • dendritic spine • dendritic shaft Biological process • cytoplasmic microtubule organization • protein localization to microtubule • establishment of protein localization • regulation of postsynaptic density protein 95 clustering Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9419	56724
Ensembl	ENSG00000119878	ENSMUSG00000024146
UniProt	Q9P021	O70333
RefSeq (mRNA)	NM_014171	NM_019936
RefSeq (protein)	NP_054890	NP_064320
Location (UCSC)	Chr 2: 46.62 – 46.63 Mb	Chr 17: 87.03 – 87.04 Mb
PubMed search

Cysteine-rich PDZ-binding protein is a protein that in humans is encoded by the CRIPT gene.^{[1][2][3][4][5]}

Interactions

CRIPT has been shown to interact with DLG3.^[6]

References

1. Fukunaga Y, Matsubara M, Nagai R, Miyazawa A (Aug 2005). "The interaction between PSD-95 and Ca2+/calmodulin is enhanced by PDZ-binding proteins". J Biochem 138 (2): 177–82. doi:10.1093/jb/mvi107. PMID 16091592.
2. Piserchio A, Pellegrini M, Mehta S, Blackman SM, Garcia EP, Marshall J, Mierke DF (Feb 2002). "The PDZ1 domain of SAP90. Characterization of structure and binding". J Biol Chem 277 (9): 6967–73. doi:10.1074/jbc.M109453200. PMID 11744724.
3. Passafaro M, Sala C, Niethammer M, Sheng M (Jan 2000). "Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95". Nat Neurosci 2 (12): 1063–9. doi:10.1038/15990. PMID 10570482.
4. Niethammer M, Valtschanoff JG, Kapoor TM, Allison DW, Weinberg RJ, Craig AM, Sheng M (Jun 1998). "CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90". Neuron 20 (4): 693–707. doi:10.1016/S0896-6273(00)81009-0. PMID 9581762.
5. "Entrez Gene: CRIPT cysteine-rich PDZ-binding protein".
6. Lim, Indra Adi; Hall Duane D; Hell Johannes W (Jun 2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". J. Biol. Chem. (United States) 277 (24): 21697–711. doi:10.1074/jbc.M112339200. ISSN 0021-9258. PMID 11937501.

Further reading

• Zhang QH, Ye M, Wu XY; et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Lim IA, Hall DD, Hell JW (2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102.". J. Biol. Chem. 277 (24): 21697–711. doi:10.1074/jbc.M112339200. PMID 11937501.
• Cai C, Coleman SK, Niemi K, Keinänen K (2002). "Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif.". J. Biol. Chem. 277 (35): 31484–90. doi:10.1074/jbc.M204354200. PMID 12070168.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G (2007). "Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays.". J. Am. Chem. Soc. 128 (17): 5913–22. doi:10.1021/ja060943h. PMC 2533859. PMID 16637659.
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.