CSN2
| Casein beta | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | CSN2 ; CASB | ||||||||||||
| External IDs | OMIM: 115460 MGI: 88541 HomoloGene: 1426 GeneCards: CSN2 Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 1447 | 12991 | |||||||||||
| Ensembl | ENSG00000135222 | ENSMUSG00000063157 | |||||||||||
| UniProt | P05814 | P10598 | |||||||||||
| RefSeq (mRNA) | NM_001302770 | NM_001286020 | |||||||||||
| RefSeq (protein) | NP_001289699 | NP_001272949 | |||||||||||
| Location (UCSC) |
Chr 4: 69.96 – 69.96 Mb |
Chr 5: 87.69 – 87.7 Mb | |||||||||||
| PubMed search | |||||||||||||
Beta-casein is a protein that in humans is encoded by the CSN2 gene.[1][2] It is in the class of phosphoproteins and generally occurs in mammalian milk.
References
- ↑ Menon RS, Chang YF, Jeffers KF, Jones C, Ham RG (Jun 1992). "Regional localization of human beta-casein gene (CSN2) to 4pter-q21". Genomics 13 (1): 225–6. doi:10.1016/0888-7543(92)90227-J. PMID 1577486.
- ↑ "Entrez Gene: CSN2 casein beta".
Further reading
- Letwin K, Mizzen L, Motro B; et al. (1992). "A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells.". EMBO J. 11 (10): 3521–31. PMC 556810. PMID 1382974.
- Lönnerdal B, Bergström S, Andersson Y; et al. (1990). "Cloning and sequencing of a cDNA encoding human milk beta-casein.". FEBS Lett. 269 (1): 153–6. doi:10.1016/0014-5793(90)81142-B. PMID 2387396.
- Menon RS, Ham RG (1989). "Human beta-casein: partial cDNA sequence and apparent polymorphism.". Nucleic Acids Res. 17 (7): 2869. doi:10.1093/nar/17.7.2869. PMC 317677. PMID 2717418.
- Greenberg R, Groves ML, Dower HJ (1984). "Human beta-casein. Amino acid sequence and identification of phosphorylation sites.". J. Biol. Chem. 259 (8): 5132–8. PMID 6715339.
- Chen CS, Bejcek BE, Kersey JH (1995). "A mapping study of 13 genes on human chromosome bands 4q11→q25.". Cytogenet. Cell Genet. 69 (3–4): 260–5. doi:10.1159/000133976. PMID 7698025.
- Hansson L, Edlund A, Johansson T; et al. (1994). "Structure of the human beta-casein encoding gene". Gene 139 (2): 193–9. doi:10.1016/0378-1119(94)90754-4. PMID 8112603.
- McConkey EH, Menon R, Williams G; et al. (1996). "Assignment of the gene for beta-casein (CSN2) to 4q13 → q21 in humans and 3p13 → p12 in chimpanzees". Cytogenet. Cell Genet. 72 (1): 60–2. doi:10.1159/000134163. PMID 8565637.
- Wilmouth RC, Clifton IJ, Robinson CV; et al. (1997). "Structure of a specific acyl-enzyme complex formed between beta-casomorphin-7 and porcine pancreatic elastase". Nat. Struct. Biol. 4 (6): 456–62. doi:10.1038/nsb0697-456. PMID 9187653.
- Winklehner-Jennewein P, Geymayer S, Lechner J; et al. (1998). "A distal enhancer region in the human beta-casein gene mediates the response to prolactin and glucocorticoid hormones". Gene 217 (1–2): 127–39. doi:10.1016/S0378-1119(98)00380-1. PMID 9795185.
- Gray CW, Ward RV, Karran E; et al. (2000). "Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response". Eur. J. Biochem. 267 (18): 5699–710. doi:10.1046/j.1432-1327.2000.01589.x. PMID 10971580.
- Sood SM, Slatter CW (2003). "Suspension of the calcium-sensitive human beta-caseins by human kappa-casein". J. Dairy Sci. 85 (6): 1353–6. doi:10.3168/jds.S0022-0302(02)74200-8. PMID 12146463.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ohashi A, Murata E, Yamamoto K; et al. (2003). "New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors". Biochem. Biophys. Res. Commun. 306 (1): 98–103. doi:10.1016/S0006-291X(03)00917-3. PMID 12788072.
- Reimer T, Weiwad M, Schierhorn A; et al. (2003). "Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14". J. Mol. Biol. 330 (5): 955–66. doi:10.1016/S0022-2836(03)00713-7. PMID 12860119.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Miller SL, DeMaria JE, Freier DO; et al. (2005). "Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor". Mol. Endocrinol. 19 (4): 939–49. doi:10.1210/me.2004-0443. PMID 15618286.
- Sood SM, Lekic T, Jhawar H; et al. (2007). "Reconstituted micelle formation using reduced, carboxymethylated bovine kappa-casein and human beta-casein". Protein J. 25 (5): 352–60. doi:10.1007/s10930-006-9022-7. PMID 16947075.
- Buser AC, Gass-Handel EK, Wyszomierski SL; et al. (2007). "Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells". Mol. Endocrinol. 21 (1): 106–25. doi:10.1210/me.2006-0297. PMID 16973758.
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