CSNK1E

Casein kinase 1, epsilon
PDB rendering based on 1cki.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4HNI​, 4HOK​
Identifiers
Symbols	CSNK1E ; CKIepsilon; HCKIE
External IDs	OMIM: 600863 MGI: 1351660 HomoloGene: 121695 ChEMBL: 4937 GeneCards: CSNK1E Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • poly(A) RNA binding Cellular component • nucleus • cytoplasm • cytosol • ribonucleoprotein complex Biological process • G2/M transition of mitotic cell cycle • mitotic cell cycle • DNA repair • protein phosphorylation • endocytosis • organelle organization • signal transduction • circadian rhythm • regulation of cell shape • Wnt signaling pathway • peptidyl-serine phosphorylation • negative regulation of Wnt signaling pathway • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • circadian regulation of gene expression • cellular protein localization • regulation of circadian rhythm • positive regulation of canonical Wnt signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1454	27373
Ensembl	ENSG00000213923	ENSMUSG00000022433
UniProt	P49674	Q9JMK2
RefSeq (mRNA)	NM_001894	NM_001289898
RefSeq (protein)	NP_001885	NP_001276827
Location (UCSC)	Chr 22: 38.29 – 38.4 Mb	Chr 15: 79.42 – 79.44 Mb
PubMed search

Casein kinase I isoform epsilon is an enzyme that in humans is encoded by the CSNK1E gene.^[1][2]

Function

The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate proteins of the Period family of circadian rhythm proteins. A homolog of this mammalian protein can be found in Drosophila melanogaster. Known as doubletime, this protein also plays a role in the phosphorylation of proteins involved in circadian rhythms. Two transcript variants encoding the same protein have been found for this gene.^[3]

Interactions

CSNK1E has been shown to interact with PER1^[4] and AXIN1.^[5]

Inhibitors

Selective

• PF-4800567

Non-selective

• PF-670462 (also inhibits CK1-δ)

References

1. Fish KJ, Cegielska A, Getman ME, Landes GM, Virshup DM (Jun 1995). "Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family". The Journal of Biological Chemistry 270 (25): 14875–83. doi:10.1074/jbc.270.25.14875. PMID 7797465.
2. Sakanaka C, Leong P, Xu L, Harrison SD, Williams LT (Oct 1999). "Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function". Proceedings of the National Academy of Sciences of the United States of America 96 (22): 12548–52. doi:10.1073/pnas.96.22.12548. PMC 22983. PMID 10535959.
3. "Entrez Gene: CSNK1E casein kinase 1, epsilon".
4. Vielhaber E, Eide E, Rivers A, Gao ZH, Virshup DM (Jul 2000). "Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon". Molecular and Cellular Biology 20 (13): 4888–99. doi:10.1128/MCB.20.13.4888-4899.2000. PMC 85940. PMID 10848614.
5. Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC (May 2002). "Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways". The Journal of Biological Chemistry 277 (20): 17706–12. doi:10.1074/jbc.M111982200. PMID 11884395.