CST6 (gene)

Cystatin E/M
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol CST6
External IDs OMIM: 601891 MGI: 1920970 HomoloGene: 1011 GeneCards: CST6 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 1474 73720
Ensembl ENSG00000175315 ENSMUSG00000024846
UniProt Q15828 Q8K397
RefSeq (mRNA) NM_001323 NM_028623
RefSeq (protein) NP_001314 NP_082899
Location (UCSC) Chr 11:
66.01 – 66.01 Mb
Chr 19:
5.34 – 5.35 Mb
PubMed search

Cystatin-M is a protein that in humans is encoded by the CST6 gene.[1][2][3]

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype.[3]

References

  1. Stenman G, Astrom AK, Roijer E, Sotiropoulou G, Zhang M, Sager R (Jun 1997). "Assignment of a novel cysteine proteinase inhibitor (CST6) to 11q13 by fluorescence in situ hybridization". Cytogenet Cell Genet 76 (1-2): 45–6. doi:10.1159/000134512. PMID 9154125.
  2. Ni J, Abrahamson M, Zhang M, Fernandez MA, Grubb A, Su J, Yu GL, Li Y, Parmelee D, Xing L, Coleman TA, Gentz S, Thotakura R, Nguyen N, Hesselberg M, Gentz R (May 1997). "Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins". J Biol Chem 272 (16): 10853–8. doi:10.1074/jbc.272.16.10853. PMID 9099741.
  3. 1 2 "Entrez Gene: CST6 cystatin E/M".

External links

Further reading

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